Clinical Manifestations Of 9 Cases Of Cryptogenic Organizing Pneumonia

Objective: By reviewing the data of patients with cryptogenic organizing pneumonia and summarizing the features of clinical,images,pathological characteristics,to improving clinicians’ awareness and diagnosis of the disease and avoiding the missed diagnosis and misdiagnosis.Methods: In this survey,we retrospectively reviewed 9 subjects with cryptogenic organizing pneumonia in the Second Hospital of Hebei Medical University between January of 2012 and December of 2017,in order to analyze the epidemiology,clinical manifestations,laboratory tests,images,pathological features of cryptogenic organizing pneumonia.Results: There were 4 females and 5 males,with a mean age of55.44±18.49 years,none of them had dust inhalation,77.78% were nonsmokers.All patients had a subacute onset and the median medical history was 23 days(maximum medical history up to 180 days).Clinical manifestations include cough,dyspnea,fever,but also accompanied by fatigue,anorexia and other systemic symptoms,physical examination shows crackles or wet rales.The C-reactive protein level and erythrocyte sedimentation rate were increased.Blood gas analysis showed hypoxemia,and lung function test mainly showed restrictive ventilatory dysfunction and diffusion dysfunction.The common imaging manifestations include consolidation,ground glass opacity,etc.The main pathological feature is that the granulation tissue is filled with alveolar cavity.After corticosteroid treatment,the symptoms and imaging were obviously reduced,but it ofen has a relapse.The rate of misdiagnosis was high,the median duration of diagnosis was 41 days(The longest misdiagnosis time is up to 201 days).Conclusion: The clinical-radiological-pathological diagnosis is the most important diagnostic method,and the diagnosis of COP requires the exclusionof secondary factors.The clinical features of COP are lack of specificity.Images are easy to be confused with diseases such as pneumonia and so on.The effect of corticosteroid treatment is good.To improve the understanding of the disease and the early pathological examination is helpful to the diagnosis.