Expression Of VMP1 And TP53INP2 In Eutopic Endothelial Cells After UCA1 Silencing

Objective: Silencing endometriosis patients in endometrial cells UCA1,the detection of Vmp1,TP53INP2 expression levels,explore Vmp1,TP53INP2 in endometriosis in the mechanism.Methods: Six cases of eutopic endometrial cells after virus transfection confirmed by paraffin pathology in patients with ovarian endometriosis were selected and divided into UCA1 gene silencing group(si-UCA1),transfected negative control group(ESCs-C)And untransfected group(ESCs).The expression of Vmp1 and TP53INP2 in eutopic endometrial cells of endometriosis patients were detected by real-time quantitative polymerase chain reaction(qRT-PCR)Analyze its relevance.Results: The relative expression level of Vmp1 mRNA in si-UCA1 group was significantly higher than that in ESCs group(2.64±0.367 VS 1,P<0.05);the relative expression level of TP53INP2 mRNA in si-UCA1 group was significantly higher than that in ESCs group(10.83±2.230 VS 1,P<0.01);ESCs-c group Vmp1 mRNA,TP53INP2 mRNA relative expression levels and ESCs group had no significant difference(P> 0.05).Conclusions: Highly expressed UCA1 in endometriosis in patients with endometriosis inhibited the expression of Vmp1 and TP53INP2 and inhibited the occurrence of autophagy.