Study On The Relationship Between Serum Vitamin D Level And Homocysteine Level In Patients With Type 2 Diabetes With Coronary Atherosclerosis

Objective: To investigate whether the serum vitamin d level is related to the severity of coronary artery disease in type 2 diabetes mellitus.Methods: Choose 366 cases of type 2 diabetes who were hospitalized in Shengjing Hospital from January 5,2016 to September 29,2017 and coronary angiography was performed on all the above subjects.Fasting their serum vitamin D levels,homocysteine,blood routine,liver function,renal function,blood glucose,glycosylated hemoglobin,urinary albumin/urine creatinine,calcium,phosphorus,magnesium,blood lipid,hs CRP and other biochemical indicators.According to coronary angiography,the subjects were divided into non-coronary heart disease group and coronary heart disease group,and according to Gensini improved score standard,the subjects were divided into: Mild sclerosis group: 0-4 points;moderate sclerosis group: 5-9 points;severe sclerosis group: > 10 points.Compare the difference between the levels of vitamin D and homocysteine in each group,and analyzed the correlation between the two groups.Results:1.Coronary heart disease group serum vitamin D levels were significantly lower than non-coronary heart disease group,homocysteine levels were significantly higher than non-coronary heart disease group.2.Vitamin d level in mild sclerosis group(18.37ng/ml)> moderate sclerosis group(14.66 ng/ml)>severe sclerosis group(13.31ng/ml).Homocysteine level in mild sclerosis group was 9.89 umol/L<moderate sclerosing group in 11.86 umol/L < severe sclerosis group in 13.55 umol/L group.3.There was a negative correlation between serum vitamin d level and serum homocysteine level in diabetic patients with coronary atherosclerosis(r =-0.167,p < 0.05).Conclusion: Low vitamin d and hyperhomocysteinemia are risk factors for type 2 diabetes with cardiovascular disease,Vitamin d is closely related to the severity of coronary atherosclerosis in diabetic patients.The lower the level of vitamin d,the higher the severity of coronary artery lesion.