Analysis Of Risk Factors Related To Cerebral Microbleeds In Patients With Ischemic Stroke

Purpose:Cerebral microbleeds is increasingly related to the clinical neurology.We study the imaging and clinical data of patients with ischemic stroke,to explore the relevant risk factors of cerebral microbleeds,so that prevent or improve the course of cerebral microbleeds,and provide guidance for clinical treatment of cerebrovascular disease.Methods:Ninety-nine patients diagnosed with ischemic stroke who were in hospital from January 2015 to November 2017 were enrolled in this study.The number and locations of cerebral microbleeds were recorded,as well as patients' clinical information including age,gender,hypertension,diabetes mellitus,blood lipid levels,smoking,alcohol consumption,homocysteine,Leukoaraiosis,lacunar infarction numbers vascular atherosclerosis,previous medical history and so on.The 99 patients were divided into cerebral microbleeds group and non-cerebral microbleeds group,Including 54 cases and 45 cases respectively,and relevant information were statistically analyzed.54 patients with cerebral microbleeds were further divided into infratentorial group,deep group,lobar group,and mixed group according to the different distribution,and the difference between four groups were statistically analyzed.In this study,43 patients were diagnosed acute cerebral infarction,who were also divided into cerebral microbleeds group and non-cerebral microbleeds group.Statistical analysis were also performed in the two groups of data.Moreover,we apply SPSS22.0 software to analyze the data,and P <0.05 means statistically significant.Results:1.There are 54 patients with cerebral microbleeds,occupying the54.5% of the total,and there are the most microbleeds located in the lobar area.43 patients were diagnosed acute cerebral infarction,of which the portion of cerebral microbleeds was 41.9%.2.Age,hypertension,leukoaraiosis and lacunar infarcts were significantly different between cerebral microbleeds groups and non-cerebral microbleeds groups(P <0.05),however,other factors we collected were no significant difference(P> 0.05).Logistic regression analysis showed that the severity of leukoaraiosis was an independent risk factor for cerebral microbleeds,and Spearman analysis confirmed that severity of leukoaraiosis was positively related to the severity of cerebral microbleeds.3.There were statistically significant difference in age,hypertension prevalence,and severity of leukoaraiosis among the infratentorial group,deep group,lobar group and mixed group(P<0.05).Besides,the average age of the deep group was the youngest,the prevalence of hypertension was the lowest in the lobar group,the degree of leukoaraiosis in the infratentorial group was less than other groups.4.As far as the patients diagnosed acute cerebral infarction,the severity of leukoaraiosis was statistically different between cerebral microbleeds groups and non-cerebral microbleeds groups.Conclusions:Cerebral microbleeds were common in patients with ischemic stroke,mostly located in the lobar regions.The degree of leukoaraiosis was an independent risk factor for cerebral microbleeds in patients with ischemic stroke.Age,severity of leukoaraiosis,and the prevalence of hypertension were different in varied regions where cerebral microbleeds occurred.