Correlated Study Between Middle-old Aged Cerebral Microbleeds And Cardia Cerebral Vascular Risk Factors

Objective: To analyze the prevalence, distribution of middle-old aged cerebral microbleeds and the correlation between CMBs and cardial cerebral vascular risk factors in order to investigate its clinical significance.Methods: Conventional and GRE-T2* MRI were performed with 658 cases (628 patients and 30 healthy volunteers). Clinical data was counted respectively, including age, sexual, blood pressure, blood sugar, blood lipin,medication, the number of CMBs and CMBs according to their locations. 658 cases were divided into disease group (334) and control group (324); disease group was divided into hypertension group, diabetes mellitus group, hyperlipemia group, hypertension and diabetes mellitus group, hypertension and hyperlipemia group and"three high"group (hypertension, diabetes mellitus, hyperlipemia). Systolic pressure, was classified high(SP≥180mmHg), middle (140mmHg140mmHgλ=1.6787, CMBs and SP≤140mmHgλ= 0.5734.the severity and numbers of CMBs were closely correlated with severity of hypertension and course of disease(P<0.01). correlate coefficient of mean arterial blood pressure(MAP) was 0.621, age 0.287.Conclusions: It was suggested that CMBs was more likely to occur in middle-old aged people, especially in hypertension disease, hypertension and diabetes mellitus disease, hypertension and hyperlipemia disease and"three high"patients. Most CMBs occurred in brain lobes and deep region, and they also could be observed in infratentorial region. calculating the data based on the cases, deep region of disease group was the most, brain lobes in control group were the most. however , as according to the CMBs number, brain lobes of both diease group and control group were the most. The correlation were closely between CMBs and hypertension, diabetes mellitus and hyperlipemia , not only hypertension, diabetes mellitus were independent risk factors, but were cooperative factors for each other to develop CMBs. Long-term, persistent hypertension will damage microvascular. The frequency of CMBs was closely correlated with persistent time and severity of hypertension. MAP correlate coefficient was more than that of age.