The Risk Factors Of Atherosclerotic Moyamoya Syndrome And The Relationship Between Red Blood Cell Distribution Width And Plaque Stability

Objective: Through collecting the clinical data,respectively count and analyze the risk factors of atherosclerotic moyamoya syndrome and patients with atherosclerotic cerebral infarction,and the relation between the red cell distribution width and the stability of carotid atherosclerotic plaque,and investigate the pathogenesis in both difference and connection.Methods: Randomly select some patients with atherosclerotic moyamoya syndrome and some patients with atherosclerotic cerebral infarction who have been hospitalized from September 1,2015 to December 31,2017 in our neurology department,and select some healthy people who have received physical examination at the same period in our hospital,to collect gender,age and other general clinical information.Meanwhile,improve the laboratory inspection,and make statistics of two-group patients' red blood cells,hemoglobin,red cell distribution width,hematocrit,triglyceride,cholesterol,high density lipoprotein,low density lipoprotein,fasting blood glucose,glycosylated hemoglobin,and homocysteine level.Besides,improve carotid artery ultrasonography,and make statistics of the stability of carotid atherosclerotic plaque of the two-group patients,as well as analyze the relation between red cell distribution width and the stability of carotid atherosclerotic plaque.Alldata are processed and analyzed by the SPSS25.0 statistics analysis software.Results: 1.Compared with the normal control group,the triglyceride,high-density lipoprotein,low density lipoprotein,total cholesterol,glycosylated hemoglobin,homocysteine and hematocrit difference in the atherosclerotic moyamoya syndrome group is statistically significant(P <0.05).Stepwise multivariate logistic regression analysis shows that the triglyceride,homocysteine and hematocrit are the independent influence factors for atherosclerotic moyamoya syndrome(P < 0.05);combined with the OR value,it can be obtained that triglyceride(OR=8.048,95%CI=2.167-29.892,P=0.002)and homocysteine(OR=1.490,95%CI=1.117-1.978,P=0.005)are independent risk factor for atherosclerotic moyamoya syndrome;while the hematocrit(OR=0.797,95%CI=0.655-0.969,P=0.023)is independent protective factor for atherosclerotic moyamoya syndrome group.2.Compared with the normal control group,the gender,age,triglyceride,high-density lipoprotein homocysteine,glycosylated hemoglobin and red blood cell distribution width difference in the atherosclerotic cerebral infarction group is statistically significant(P <0.05).Stepwise multivariate logistic regression analysis shows that,triglyceride,high density lipoprotein,homocysteine,and red cell distribution width are independent risk factors for atherosclerotic cerebralinfarction(P < 0.05);combined with the OR value,it can be obtained that triglycerides(OR=2.324,95%CI=1.018-5.306,P=0.045),homocysteine(OR=1.449,95%CI=1.165-1.801,P=0.001),and red cell distribution width(OR=3.489,95%CI=1.566-7.777,P=0.002)are independent risk factors for atherosclerotic cerebral infarction;high density lipoprotein(OR=0.018,95%CI=0.001-0.484,P=0.017)is independent protective factor for atherosclerotic cerebral infarction.3.The age,total cholesterol,homocysteine and red blood cell distribution width in atherosclerotic cerebral infarction group is significantly higher than those in atherosclerotic moyamoya syndrome group,so the difference is statistically significant(P < 0.05).4.In the atherosclerotic moyamoya syndrome group,multivariate logistic regression analysis shows that,whether it is with correction of confounding factors or not,the red cell distribution width is not the factor influencing the stability of patients' plaque(P > 0.05).5.In the atherosclerotic cerebral infarction group,multivariate logistic regression analysis shows that,under this circumstance without adjusting confounding factors,the red cell distribution width is the factor influencing the stability of patients' plaque(OR=1.912,95%CI=1.106-3.308,P=0.020).After adjusting confounding factors,the red cell distribution width is still the factor influencing the stability of patients' plaque(OR=2.278,95%CI=1.204-4.312,P=0.011).Conclusion: 1.The triglyceride and homocysteine are independent risk factors for atherosclerotic moyamoya syndrome,and hematocrit is an independent protective factor.2.The age,triglyceride,homocysteine and red blood cell distribution width are independent risk factors for atherosclerotic cerebral infarction.High density lipoprotein is an independent protective factor.3.There is no significant correlation between the red blood cell distribution width and the stability of patients' carotid artery plaque in the atherosclerotic moyamoya syndrome group.4.The increase of red blood cell distribution width can increase the risk of forming unstable plaque in patients with atherosclerotic cerebral infarction.