Relationship Between Dyslipidemia And Preeclampsia In Pregnant Women

Objective: To study the characteristics of blood lipid metabolism in normal pregnant women and preeclampsia patients.Understand the relationship between abnormally elevated serum lipids and patients with preeclampsia.Methods: By way of retrospective analysis,a total of 294 cases of gestational hypertension during the period from January 1,2017 to December 31,2017 in the Suzhou Kowloon Hospital were collected,and the gestational period was 28 weeks to 41 weeks.69 cases of severe preeclampsia,113 cases of mild preeclampsia,67 cases of hypertension during pregnancy,22 cases of chronic hypertension complicated by preeclampsia,and 23 cases of pregnancy with chronic hypertension.Among them,severe cases of preeclampsia,mild preeclampsia and gestational hypertension were selected.In the other month,10 normal hospitalized women with no intrauterine and surgical diseases were selected as the control group for a total of 120 cases.Exclusion criteria:(1)multiple pregnancies;(2)gestational weeks less than 28 weeks of delivery;(3)pre-pregnancy polycystic ovary syndrome;(4)pre-pregnancy diabetes,heart disease;(5)abnormal thyroid function Persons with metabolic diseases;(6)Patients with autoimmune diseases;(7)Intrahepatic cholestasis of pregnancy during pregnancy.Serum total cholesterol,triglyceride,low-density lipoprotein,and high-density lipoprotein were measured for comparison.Statistics the clinical data of each group.Analyze and compare the differences in blood lipids among pregnant women in each group,assess the risk of dyslipidemia with dyslipidemia and the effect of dyslipidemia on mean arterial pressure,24-hour urine protein quantification,and low birth weight infants.Results: Compared with pregnant women with normal pregnancy,serum total cholesterol,triglycerides,and LDL concentrations in pregnant women with severe preeclampsia,mild preeclampsia,and pregnancy-induced hypertension all increased to varying degrees,with statistically significant differences.(P <0.05),and with the severity of the disease,severe dysperiasis group had milder preeclampsia and gestational hyperlipidemia with statistical significance(P <0.05).Total cholesterol was an independent risk factor for pregnancy-induced hypertension,mild preeclampsia,and severe preeclampsia.The OR values were 1.979,1.704,and 4.833,respectively.The 95 CI% were 1.446-2.711,1.253-2.318,and 1.113-20.979,respectively.TG was an independent risk factor for mild preeclampsia and severe preeclampsia.The OR values were 1.470 and 4.171,respectively.The 95CI% were 1.083-1.995 and 1.072-16.231,respectively.There was no association between TG levels and the occurrence of gestational hypertension.HDL is an independent protective factor of the three,with OR values of 0.742,0.713,and 0.000,and 95 CI% of 0.184-2.988,0.164-3.110,and 0.000-0.187,respectively.LDL was only an independent risk factor for severe preeclampsia with an OR of 4.910 and 95CI% of 1.039-23.210,respectively.LDL levels were not associated with gestational hypertension and mild preeclampsia.Conclusion: During normal pregnancy,the maternal body needs physiological reserves for the development of the fetus during pregnancy,as well as reserves energy for childbirth and postpartum reserves,resulting in a state of physiological hyperlipidemia.Compared with normal pregnancy,as the disease progresses,the serum total cholesterol,triglyceride,and low-density lipoprotein levels in the patients with hypertensive disorders complicating pregnancy are gradually increased.The difference is statistically significant(P<0.05).The difference was more pronounced in patients with severe preeclampsia.Total cholesterol is an independent risk factor for pregnancy-induced hypertension,mild preeclampsia,and severe preeclampsia.Triglycerides are independent risk factors for mild preeclampsia and severe preeclampsia.High-density lipoproteins are three Independent protective factors,low-density lipoprotein is only an independent risk factor for severe preeclampsia.Total cholesterol,triglyceride,and LDL concentrations were positively correlated with mean arterial pressure and 24-hour urinary protein,whereas high-density lipoprotein concentrations were inversely correlated with mean arterial pressure and 24-hour urine protein.High-density lipoprotein was an independent protective factor for low birth weight infants,and the remaining lipids showed no significant differences in the model.Total cholesterol,triglyceride,and low-density lipoprotein were not considered as independent risk factors for the disease.