Clinical Study On The Changes Of Serum Cystatin C Level In Patients With Cerebral Infarction

Objective:To observe the changes of serum Cys-C level in patients with cerebral infarction and different degree of cerebral vascular stenosis,and to explore the effect of Cys-C on acute cerebral infarction and cerebral vascular stenosis.Methods:We selected patients with first-time cerebral infarction who were hospitalized in Department of Neurology,Second Hospital of Jilin University from August 2016 to July 2017(n=222),meanwhile we chose people in physical examination at the Second Hospital of Jilin University as control group during the same period(n=101).Patients' gender,age,past history,alcohol and tobacco history were collected.Serum Cys-C,HCY,creatinine,fasting blood glucose,TG,TC,LDL,and HDL were examined.Patients in cerebral infarction group underwent intracranial and extracranial CT angiography.Patients with cerebral infarction were divided into group A(not more than 3 days),group B(4-7 days)and group C(more than 7 days)according to the time of onset.The cerebral infarction group was divided into groups as non-stenosis group,mild stenosis group,moderate stenosis group,severe stenosis and occlusion group according to the degree of cerebrovascular stenosis.The differences of gender,age,hypertension,diabetes,smoking,drinking and Cys-C,HCY,Cr,fasting glucose,TG,TC,LDL,HDL were analyzed and compared.The level of Cys-C in different groups divided according to time of onset was compared.Logistic regression was used to analyze the correlation between cerebral infarction,cerebral vascular stenosis and Cys-C.Results:The level of Cys-C in the cerebral infarction group was significantly higher than that in the control group(P < 0.001).Logistic regression analysis showed that serum Cys-C level was significantly associated with cerebral infarction(P = 0.001).There was no difference in Cys-C level between the three groups of patients with different onset time(P > 0.05).And there was no difference in Cys-C level in patients with different cerebral vascular stenosis(P > 0.05).Logistic regression a n a l y s i s s h o w e d t h a t t h e r e w a s n o c o r r e l a t i o n between Cys-C levels and vascular stenosis.Conclusions:(1)Cys-C is significantly associated with cerebral infarction.(2)Serum Cys-C level does not change significantly with the onset of time.(3)There is no correlation between Cys-C level and cerebrovascular stenosis.