The Relationship Of Cys C Levels In Cerebrovascular In-stent Restenosis

Objective: To study the correlation between serum cystatin C(Cys C)level and cerebrovascular in-stent restenosis.Methods: Retrospective analysis clinical data of 171 patients who underwent cerebrovasscular stent implantation,followed up for 6 to 12 months and rechencked by digital subtraction angiography(DSA)or Computed tomography angiography(CTA).According to the secondly DSA or CTA result,we devided the patients into 2 groups:In-stent restenosis(ISR)group(n=25)and Non In-stent restenosis(NISR)group(n=146).Luminal diameter stenosis ?50% of the original target lesion was used as the criterion of in-stent restenosis(ISR).We compared Cys C levels in two groups.Analysis whether age,gender,diabets,hypertension,coronary heart disease,somking,drinking,low density lipoprotein,high density lipoprotein,triglycede,uric acid,creatinine,cystatin C,total bilirubin,homocysteine,fibrinogen the factors affect In-stent restenosis.Then the patients were divided into 4 groups according to their serum Cys C level.Incidence of ISR was compared among these 4 groups.Risk factors for ISR were analyzed by Logistic regression analysis.All data were carefully verified and entried.Using SPSS 21.0 software inspected and analyzed the data,the test P< 0.05 was statistically significant.Results: Cys C levels in ISR groups(1.18±0.23)mg/L higher than NISR groups(1.04±0.30)mg/L.Cys C levels in two groups have satistically significant.The incidence of ISR and Cys C level were higher in ISR group than NISR group.Logistic regression analysis showed that Cys C level and diabetes mellitus are the independent risk factors for ISR(OR=2.658,OR=5.138).Conclusion: Cys C level in patients is positively correlated with the incidence of ISR and is a risk factor for ISR after cerebrovascular stent implantation.