Study On Immune Function Of Post-infection Cough In Children

Objective: By observing the changes of humoral immunity,cellular immunity,functional indicators of complement system in children with post-infectioncough and the detection of throat swabs and mycoplasma in children with PIC,Immune status,respiratory tract infection caused by cough immune pathogenesis,to provide a theoretical basis for clinical treatment.Methods: A retrospective study was conducted in 141 outpatients with chronic cough clinics in Dalian Children’s Hospital from October 2016 to October 2017.The 141 patients with throat swab and mycoplasma were detected by culture medium and immunoturbidimetry Humoral immune function and complement function test,flow cytometry cellular immune function testing and analysis.Result:1.141 cases of PIC children completed bacterial and mycoplasma throat swab 60 cases,mycoplasma positive in 12 cases,accounting for 20%;bacterial tests were negative.12 cases of positive mycoplasma examination were abnormal immune function.2.In 141 cases of PIC children with normal immune function was 17 cases,accounting for 12.06%;124 cases of immune dysfunction,accounting for 87.94%.Among them,61 cases(49.19%)had abnormal humoral immune function,12 cases(9.68%)had abnormal cellular immune function,1(0.81%)had immunocompromised complement,and 50(40.32%)had mixed immune dysfunction.Key words: Childhood infection cough Immune function.3.Among the 141 PIC children,107 were pre-school children(76.42%),of which 45 were infantile humoral abnormalities(42.06%),9 were abnormal cellular immune functions(8.41%),and those with abnormal complement function 0 cases,accounting for 0%.There were 34 cases in the school-age group(31.78%),of which 16 cases were abnormal humoral immune function(47.06%),3 cases were abnormal cellular immunity(8.82%),and 1 case was dysfunction(2.94%).In different age groups humoral immune function,cellular immune function,complement dysfunction rate comparison,by χ2 test,P>0.05,the difference was not statistically significant.4.In 141 cases of PIC children,there were 107 cases of preschool children and 34 cases of school-age children.Compared with normal reference group immunoglobulin in preschool group and school-age group,IgA,IgG,IgM levels were lower than the normal reference group,P <0.05,significant difference was statistically significant;IgE slightly higher than the normal reference group,P> 0.05,the difference was not significant,no statistical significance.5.In 141 cases of PIC children,there were 107 preschool children and 34 preschool children.Preschool age group and preschool age group were respectively compared with the corresponding normal reference lymphocyte subsets.The preschool age CD3+CD4+,CD3-CD19+,4/ 8Ratio were lower than the normal reference group,P <0.05,the difference was statistically significant,there was no significant difference between CD3+,CD3+CD8+,CD3-CD16+/CD56+,P>0.05.The CD3+,CD3+CD8+,CD3-CD19+,CD3-CD16+/CD56+,P>0.05 in the school-age group were lower than the normal reference group,P<0.05,the difference was statistically significant Obviously,no statistical significance.6.In 141 cases of PIC children,there were 107 preschool children and 34 preschool children.The levels of complement in pre-school age group and school-age group were respectively compared with the corresponding normal reference group.The complement C3 in both groups was lower than Corresponding to the normal reference group,P<0.05,the difference was significant and statistically significant.Two groups of complement C4 by t test,P> 0.05,the difference was not significant,no statistical significance.Conclusion:1.About 1/5 of pediatric pharyngeal swabs were positive for Mycoplasma pneumoniae and immune function were involved in the pharyngeal swab.This may be one of the reasons for persistent unrecovered cough after infection.It indirectly suggests partial immune clearance of some children with PIC.The ability may be insufficient.After the respiratory tract infection,the pharynx with mycoplasma pneumoniae should continue to be actively treated with anti-pneumonia mycoplasma.2.About 5/6 PIC children with abnormal immune function,humoral immunity and mixed immune dysfunction based.3.In PIC patients with abnormal humoral immunity,the levels of Ig A,IgG and Ig M in both groups were significantly decreased;in patients with PIC abnormalities,both groups were mainly reduced by complement C3;in PIC patients with abnormal cellular immunity Children,pre-school age group to CD3+CD4+,CD3-CD19+,4/8Ratio reduction mainly;school-age group CD3+CD4+,4/8Ratio significantly reduced.