Study On The Related Factors Of Hyperthyroidism Hypokalemia Periodic

Objective:Retrospective analysis the change characteristic of blood pressure,blood lipid,sex hormone(SH)and other parameters of hyperthyroidism hypokalemia periodic paralysis(TPP)and hyperthyroidism without hypokalemia periodic paralysis(NTPP),to explore the possible mechanism of TPP attack and provide the reference for clinical prevention and treatment.Methods:For January 2011 to February 2017 in the First affiliated hospital of Guangxi Medical University male hospitalized patients with TPP as experimental group(TPP group),with age matched male NTPP hospitalized patients as control group(NTPP group);The TPP group is also divided into the following subgroups:primary group and recurrence group,mild to moderate group and severe group.Record participants' gender,age,nationality,family history of hyperthyroidism,Body mass index(BMI),blood pressure,blood magnesium,blood calcium,blood potassium,Thyroid hormone(TH)?Thyroid stimulating hormone(TSH),SH and blood lipid.Then compare the characteristic of change between groups and also analysis the correlation between potassium and other index.Results:(1)TPP group and NTPP group were included 60 cases and 86 cases respectively,the age of two groups were 31.97 ± 9.03 years and 33.84 ± 9.81 years respectively,Zhuang nationality of two groups were 29 cases and 53 cases respectively,Han nationality of two groups were 27 cases and 31 cases respectively,with family history of hyperthyroidism of two groups were 5 cases and 11 cases respectively.(2)The analysis of TPP and NTPP group:Compared with NTPP group,the levels of high density lipoprotein(HDL)and testosterone of TPP group were significantly increase and the levels of diastolic blood pressure(DBP)was significantly decline,the difference are statistically significant(P<0.05).(3)The correlation analysis between potassium and other index:In TPP group,potassium was positively correlated with total cholesterol(TC),low density lipoprotein(LDL)and estradiol(E2)(P<0.01),and negatively correlated with prolactin(PRL)(P<0.01).In NTPP group,potassium was positive correlated with blood calcium(P<0.01),and positively correlated with follicle stimulating hormone(FSH)and luteinizing hormone(LH)after adjusting affecting factors(P<0.05).(4)The comparison of subgroups between mild to moderate group and severe group:Compared with mild to moderate group,the level of TC and LDL in severe group were significantly decline and the levels of PRL was increase(P<0.01),then the level of E2 was trend to decline(P=0.052).(5)The comparison of subgroups between primary group and recurrence group:The level of testosterone of recurrence group is trend to higher than that of primary group(P=0.077).Conclusions:(1)Increasing of HDL and testosterone and decreasing of DBP are associated with TPP attacks;(2)Decreasing of TC,LDL and E2 and increasing of PRL mag aggravate the level of potassium decline;(3)The increase of testosterone is not except associated with TPP recurrence;(3)Zhuang and Han nationality,the family history of hyperthyroidism,and the level of systolic blood pressure(SBP),blood magnesium,blood calcium,triglyceride(TG),FSH,LH and progesterone have nothing to do with TPP attack.