The Association Between Adiposity And The Risk Of Glaucoma: A Meta-analysis

Purpose.This meta-analysis was conducted to determine the potential association between adiposity and glaucoma incidence.Materials and Methods.A comprehensive literature search was performed in PubMed and ISI Web of Science.A meta-analysis was conducted using STATA software.Results.Fifteen eligible studies involving 2,445,980 individuals were included to investigate the association between adiposity and glaucoma incidence.The relative ratio(RR)were pooled with 95% confidence intervals(CI)by using a random-effects model.The pooled RR between adiposity and elevated intraocular pressure(IOP)was 1.73(95% CI,1.18–2.54),whereas that between adiposity and open-angle glaucoma(OAG)was 0.97(95% CI,0.83–1.13).The pooled RR between abdominal adiposity and glaucoma was 1.28(95% CI,1.15–1.41),whereas that between general adiposity and glaucoma was 1.09(95% CI,0.87–1.37).Results of subgroup analysis by sex indicated the association between adiposity and glaucoma in female group(RR,1.31;95% CI,1.05–1.64),but not in male group(RR,1.11;95% CI,0.77–1.60).The pooled RR of cohort studies and cross-sectional studies were 1.00(95% CI,0.84-1.20)and 1.22(95% CI,0.89-1.66)respectively.Conclusions.Adiposity has a higher risk of elevated IOP and abdominal adiposity has a positive association with glaucoma,especially in female patients.