The Treatment And Characteristics Of Ambulatory Blood Pressure In Patients With Essential Hypertension And Dyslipidemia

Objective: To investigate the relationship between ambulatory blood pressure and lipid in hypertension patients.Methods:Selected150 patients with primary hypertension,conducted dynamic blood pressure measurement,measured low density lipoprotein cholesterol(Low density lipoprotein cholesterol,LDL-C)level.Tested a series of lipid indexes,collected and calculated a series of dynamic parameters of blood pressure.Results:Dyslipidemia group compared with the normal lipid group:24 h mSBP(149.60±5.70 mmHg VS 139.93±4.18mmHg)?dmSBP(152.60±5.7mmHg VS 142.86±4.41mmHg)?nmSBP(147.52±6.05 mmHg VS 134.88±5.70mmHg)?24hSBPV(12.33±0.89 mmHg VS 9.70±0.58mmHg)?dSBPV(10.72±2.24 mmHg VS 9.46±0.63mmHg)?nSBPV(10.49±1.88 mmHg VS 9.13±0.69mmHg),morning systolic blood pressure surge(35.53±2.98 mmHg VS 27.29±3.38mmHg)were higher,P<0.05;24 h mDBP(93.73±6.96 mmHg VS 93.01±6.56mmHg)?dmDBP(98.99±8.03 mmHg VS 96.97±6.97mmHg)?nmDBP(89.56±6.10 mmHg VS 88.01±6.56mmHg)were higher,P>0.05,but the difference was not statistically significant.The dyslipidemia group showed more "non dipper blood pressure" pattern(66.67% VS 28.00%)than the other.Conclusion: 24 hours ambulatory blood pressure can comprehensively evaluate the association among blood pressure level,blood pressure rhythm,and blood pressure variability with abnormal lipid metabolism.Objective:To observe the effect of fluvastatin sustained-release tablets in the treatment of dyslipidemia with efficacy and safety in patients with hypertension.Methods:Selected 115 patients of dyslipidemia with mild to moderate hypertension treated with fluvastatin sustained-release tablets 80 mg once every night,12 weeks follow-up,blood lipid,high sensitive C reactive protein(hs-CRP),24 hour ambulatory blood pressure parameters were measured before and after treatment,and the comparison and correlation analysis was made.Results:First,after treatment compared with before treatment,TC(3.18±0.47 mmol/L VS 7.20±0.56 mmol/L)?LDH-C(1.75±0.68mmol/L VS 3.85±0.79mmol/L)?TG(1.71±0.18mmol/L VS 2.63±0.42mmol/L)?hs-CRP(1.32±0.17mg/L VS 4.97±0.13mg/L)were significantly lower(P<0.05),were significantly lower(P<0.05);HDL-C(1.09±0.23mmol/L VS 0.72±0.24mmol/L)were higher(P<0.05).Second,24 hm SBP(135.2 ± 9.5mm Hg VS 159.2 ±7.3mm Hg)? 24 hm DBP(88.8 ± 5.2mm Hg VS 99.4 ± 8.3mm Hg),d SBP(130.2 ± 5.5mm Hg VS160.3 ± 9.3mm Hg),d DBP(86.8 ± 10.2mm Hg VS 99.7 ± 8.3mm Hg),n SBP(128.5 ±8.5mm Hg VS 138.7±7.3mm Hg)? n DBP(68.2±4.6 mm Hg VS 79.5±6.3mm Hg),d SBPV(12.8±1.8 mm Hg VS14.7±2.4mm Hg),d DBPV(11.1±1.5mm Hg VS 13.50±2.08 mm Hg)were lower.Conclusion:Fluvastatin has reliable curative effect in lowering lipid,at the same time can be anti-inflammatory,involved in blood pressure rhythm adjustment.