Study On The Relationship Between Urinary Iodine Level And Thyroid Disease In Hefei

Objective:Through comparative analysis of urinary iodine levels in patients with thyroid disease and healthy people in Hefei city,the relationship between urinary iodine levels and the prevalence of thyroid diseases in urban residents was explored to provide clinical data for the scientific prevention and treatment of iodine-related thyroid diseases.Methods:A prospective study was used in the study.A total of 238 patients with thyroid disease were enrolled in the Third Affiliated Hospital of Anhui Medical University from March 2015 to January 2017,and these patients were divided into three groups: Graves' s disease(GD)group(n = 116),chronic lymphocyticthyroiditis(HT)group(n = 79)and thyroid nodule group(n = 43),568 cases of Hefei urban residents without thyroid disease were selected as control group Urinary iodine was measured by arsenic-cerium catalyzed spectrophotometry.Thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)were measured by chemiluminescence immunoassay.The thyroid was examined through B ultrasonography in both the case group and the control group.Results:The median urinary iodine concentrations(MUIC)of GD group,HT group,thyroid nodule group and control group were 326.83,361.49,235.26,and 195.63?g/L,there were significant differences in the MUIC between the 4 groups(H=20.13,P<0.05).The MUIC of GD group and HT group were higher than that of control group(Z=5.395,6.269,P<0.05).The MUIC was significantly different between the HT group and the thyroid nodule group(Z=3.852,P<0.05).There were significant differences in TSH,FT3,FT4,TPOAb,TgAb between the GD group and the control group(P<0.05);the TPOAb and TgAb in the HT group and thyroid nodule group were statistically significantly different compared with those of control group(P<0.05).There was no correlation between the level of urinary iodine level and FT3,FT4,TSH,TPOAb and TgAb in the 4 groups(P>0.05).Conclusion:Hefei city residents iodine nutrition at a sufficient level and Iodine supplement needs individual difference,scientific and reasonable;High urinary iodine is associated with thyroid disease,and excessive iodine intake can promote the high incidence of thyroid disease.