The Changes Of Heart Rate Variability In Patients With Cerebral Artery Stenosis

Objective To explore the changes of heart rate variability(HRV)in patients with cerebral artery stenosis(CAS).Methods The175 patients with CAS and 60 patients with no cerebral artery stenosis(CAS)were Selected,They were treated as the observation group and the control group.General state of health and Neurological symptoms and signs,other auxiliary examinationsof all patients were recorded.The 24 h HRV analysis technology was employed to compare and measure the degree of activity impairment of their cardiac autonomic nervous.According to the presence of acute cerebral infarction,the locations of CAS,number of CAS were divided into several subgroups: the impact of these factors on HRV was analyzed.Results HRV indexes in patients with CAS showed that time-domain parameters standard deviation of normal to normal interbeat intervals(SDNN),root mean square of square sum of adjacent NN interval differences(SDANN),square root of the mean squared successive differences between normal-to-normal RR intervals(RMSSD),percentage of adjacent normal-to-normal intervals that differed more than 50ms(p NN50),high-frequency power(HF)were all significantly reduced as compared with those in the control group(all P<0.05).While,sympathetic vagal balance index(LF/HF)were significantly increased in the CAS group(P<0.05).The HRV indexes of CAS and CI group were compared with CAS without CI and control group,The LF/HF indexincreased(P<0.05),and the other HRV indexes were significantly decreased(all P<0.05).Compared with the control group,the LF/HF index increased in patients with CAS without CI(P<0.05),and the other indexes decreased(all P<0.05).In patient with CAS of posterior circulation,SDNN,SDANN,total power(TP)were significantly lower than those CAS of anterior circulation(all P<0.05),The LF/HF index and the LF/HF index significantly increased(P<0.05).In addition to the high-frequency power(HF),the HRV indexes of the three CAS groups were significantly lower than that of the <3 CAS group(all P<0.05),and the LF/HF index was significantly higher than that of the <3 CAS group(all P<0.05).Conclusion CAS will cause the autonomic nervous dysfunction and affect the parameters of HRV.The damage degree of cerebral infarction with CAS is more severe,The most obvious is the stenosis of posterior circulation and the stenosis of multiple vessels.