Clinical Value Of Serum Markers About Screening People In High Risk Of Gastric Cancer Among Chronic Gastritis

Background and Objective: Pathological diagnosis is the Gold standard of sreening gastric cancer,but serum markers show advantage to some extent.objective of this research is to asess relaotionship between serum level of PG,G-17,Hp antibodies and atrophy,IM,IN,OLGA staging,OLGIM staging by detecting serum markers.And in order to verify ability of ABC method about screening GC risk in many people of Anhui province who suffered from chronic gastritis.Meanwhile,to asess consistency between serum markers and pathological result by follow-up in CAG patients who infected and eradicated Hp.Methods: Patients who suffered epigastric discomfort and saw a doctor from November 2014 to November 2017 were enrolled in the study,so as to observe influence factors of atrophy,IM and IN.And to observe Serum markers level of patients with different severity,extent of gastric precancerouse lesions and OLGA staging,OLGIM staging.And to observe distribution of atrophy,IM and IN in ABC method.At the same time,to observe change about Serum markers level,gastric precancerouse lesions,OLGA staging,OLGIM staging and ABC method 6 and 12 months after Hp eradication.Results: 1.A total of 331 patients were enrolled in the study,including 194 men and 146 women,age was not significantly different between men and women.And we found 204 cases of mucosal atrophy,147 cases of IM,74 cases of IN among those patients.2.Percentage of IN in men was higher than in women(P=0.020);There were more people suffered atrophy,IM and IN who was greater than 40 years old;Percentage of atrophy and IM was higher for those who eradicated Hp before;Smokers and drinkers were more likely to get IN;Percentage of IM was higher for those who had family history of GC.3.Serum PGI and PGR level of severe atrophy patients decreased compare to non-atrophy patients;compare to those who had no IM,Serum G-17 level of moderate IM patients and Serum PGI level of severe IM patients decreased.Meanwhile,Serum G-17 level in those who suffered IM only in antrum as well as Serum PGI level in those who suffered IM in both antrum and corpus decreased significantly.4.In OLGA staging,Serum PGI and PGR level of staging IV was lower than staging 0.While in OLGIM staging,Serum G-17 level of staging II,Serum PGI and PGR level of staging IV were lower than staging 0.5.Compare to group A,percentage of atrophy in Group B and C were higher,while those who suffered from IM in group D were more than group A.6.In pollow-up research,patients we enrolled who suffered from CAG were 36 cases 6 months after Hp eradication while 51 cases 12 months after Hp eradication.Serum G-17 level of CAG was lower,patients of staging III in OLGA staging decreased and patients of group A incrsased 6 months after Hp eradication.While 12 month after Hp eradication,Serum PGR level of CAG became higher,Serum G-17 level was still lower,Pecentage of atrophy decreased,patients of staging 0 in OLGA staging and staging I in OLGIM staging increased.Conclusions: Serum PG and G-17 level show gerat relationship with severity as well as extent of Atrophy,IM and IN.Meanwhile,serum PG and G-17 level are effective means to reflact severity of OLGA staging and OLGIM staging.At the same time,ABC method is helpful for diagnosing gastric precancerouse lesions and detecting people in high risk of gastric cancer.Because of its false negative to some extent,it's better to carry on gastroscopy and Pathological diagnosis for men older than forty companying smoking,drinking,Hp eradication before and family history of GC.it's helpful to eradicate Hp for patient who infected Hp.