Effect Of Intensive Statin Therapy On Ox-LDL And CRP In Patients With Acute Cerebral Infarction

objective To analyze the regulation effect of intensive atorvastatin on blood lipid index and inflammatory factors of patients with acute cerebral infarction treatment,and to analyze the impact of long-term use of intensive statin therapy on neurological function and the ability of daily lifein patients with acute cerebral infarction.To explore the dverse reaction conditions of different doses of statins on patients with acute cerebral infarction,to provide the basis for clinical treatment of acute cerebral infarction and statins' effective and safe dosage.Method A total of 100 cases with acute cerebral infarction were randomly selected in our hospital for treatment,and the patients were divided into experimental and control groups according to the random number list method,50 cases in each group.Two groups of patients were given conventional neuroprotective and coagulation treatment.The patients in the control group were taken the routine dosage of atorvastatin treatment,and the dosage of atorvastatin was 20mg/d,once a day.The patients in the experimental group were examined by atorvastatin treatment,and the dosage of atorvastatin was 40mg/d,once a day.Before treatment and after treatment 14 days,serum oxidized low density lipoprotein(ox-LDL),C reactive protein and hepatic function index,and the adverse reactions of patients in the two groups were respectively detected and observed.The neurological function and activities of daily living of the two groups were evaluated and compared between the two groups before treatment and after three months.The clinical efficacy of the two groups was compared.The data were used SPSS 22 statistical software for processing and analysis.The measurement data such as LDL-C content showed as(average ± standard deviation),and the data conformed to the normal distribution were used the t test,or used analysis of variance.The count data such as incidence of adverse reaction showed as(%),and the data were used the chi square test.Result(1)For 14 days after treatment,serum lipids,serum oxidized low density lipoproteinand LDL-C levels of patients in the two groups were significantly lower than those before treatment,and there were statistical significance difference(P < 0.05).For 14 days after treatment,HDL-C levels of patients in the two groups was significantly increased than that before treatment,and there were statistical significance difference(P < 0.05).For 14 days after treatment,blood lipids TG,TC and LDL-C levels,serum lipoprotein oxidized low density and C reactive protein levels in the experimental group were significantly lower than those in the control group,and there were statistical significance difference between the two groups(P < 0.05).The level of HDL-C of the patients in the experimental group increased significantly than that in the control group,and there was statistical significant difference between the two groups(P < 0.05).(2)For three months after treatment,neurological function score of patients in the two groups was significantly lower than that before treatment,and there was statistical significant difference(P < 0.05).The activities of daily livingscore of patients in the two groups was significantly higher than that before treatment,and there was statistical significant difference(P < 0.05).For three months after treatment,the nerve function defect score of patients in the experimental group was significantly lower than that in the control group,and there was statistical significant difference between the two groups(P < 0.05).The ADL scores of patients in the experimental group increased significantly than that in the control group,and there was statistical significant difference between the two groups(P < 0.05).(3)The total effective rate of the clinical treatment in the experimental group was significantly higher than that in the control group,and and there was the statistically significant difference between the two groups(P<0.05).(4)There were no statistical difference in liver function index ALT,AST and CK between the two groups before and after treatment three months(P>0.05).(5)There were no statistically significant differences in the incidence of adverse events and impairment of liver function between the two groups(P > 0.05).Conclusion(1)The intensive statin therapy can effectively control the blood lipid indexes levels of patients with acute cerebral infarction,reduce the content of oxidized low density lipoprotein,which can effectively reduce the level of CRP level.(2)The intensive statin therapy can effectively improve the neurological function in patients with acute cerebral infarction,and effectivelyenhance the patients' activities of daily living with acute cerebral infarction.In the meantime the intensive statin therapy doesn't increase the adverse reactions and liver function impairment in patients with acute cerebral infarction.