Study On Variation Of Clinical And Physicochemical Characteristics Of Gallstones In Southern Hebei

Objective:To study the clinical and physicochemical characteristics and variations of gallstones in southern Hebei in recent years(September,2015-January,2018).Methods:Collect 125 case of cholelithiasis confirmed by surgery in general surgery V of Affiliated Hospital of Hebei University of Engineering,32 males and 93 females,average age 56.Use the Gallstone Clinical Data Questionnaire to collect clinical data and physical properties,and chemical analysis to determine cholesterol and bilirubins’ content.The data are analyzed by Excel 2013 and SPSS 22.0.Compared with the characteristics of gallstones(1994 group)in the southern Hebei.Results:Compared with the 1994 group,no significant differences existed in Gender composition.The peak age was 51 to 60(52/125.41.60%)and Farmer gallstones increased.In 2018 group,cholesterol 56 cases,mixed 37 cases,pigment 32 cases,cholesterol stones increased;and gall bladder 97 cases,merged Bile duct 15 cases,extrahepatic bile duct 8 cases,intrahepatic bile duct 5 cases,no significant differences existed in composition change.Combined with acute cholecystitis 21 cases,chronic cholecystitis 104 cases,gallbladder carcinoma 4 cases,acute pancreatitis 3 cases,obstructive jaundice 8 cases.Profile analyzed,The highest proportion was cholesterol(40/60,66.67%).In 2018 group,Farmer cholelithiasis was 94 cases,no significant differences existed in stone part composition of Farmer cholelithiasis.Both males and females compared with 1994,Cholesterol calculus was significantly increased but no change in different part.Both gall bladder and merged Bile duct,in 2018 group cholesterol calculus were obviously higher than the 1994 group.Conclusions:Gallstones in southern Hebei was common in rural areas and in women,peak age was 51 to 60;Stones occurred in the gallbladder mainly;gallbladder stones were cholesterol stones mainly,and bile duct stones were primary pigment stones.The incidence of gallstones combined with gallbladder cancer is 3.2%.Over the past 20 years,gallstones in gallbladder had increased significantly;Cholesterol stones are significant increase in both males and females;Increased proportion of cholesterol stones in gall bladder and merged bile duct stones.