Pathological And Clinical Analysis Of 9768 Patients With Primary Membranous Nephropathy In Southern Hebei Province

Objective:To retrospectively analyze the pathological and clinical data of 9768 patients with primary membranous nephropathy in southern hebei province in recent 20 years.Methods:The clinical manifestations,pathological data and laboratory data of patients diagnosed with primary membranous nephropathy in the renal pathology department of the second hospital of hebei medical university were collected and analyzed by statistical methods.Results:1.The proportion of primary membranous nephropathy in renal biopsy patients in southern hebei increased year by year,significantly higher than that in other regions of China.2.Primary membranous nephropathy was mainly in middle-aged and elderly patients,with a median age of 48 years and a male-female ratio of1.27:1.The proportion of older people increased.3.Primary membranous nephropathy was characterized by nephrotic syndrome,with edema in 88%of patients.Compared with the young and middle-aged group,the urine protein and blood albumin of the elderly group were higher,but the total triglyceride was lower,and the serum creatinine was higher.However,it was considered that the blood triglyceride and serum creatinine attenuated naturally with age.About 82.5%of adults with primary membranous nephropathy had eGFR?90ml/min/1.73m~2,while only 0.6%of patients with eGFR<15ml/min/1.73m~2.4.The pathological staging of primary membranous nephropathy was still the largest in the group with stage I membranous nephropathy,which was more common in the elderly group.In recent years,the proportion decreased,while the proportion of atypical membranous nephropathy increased,which was more common in the group with young children.Idiopathic membranous nephropathy with FSGS disorders(accounting for 4.3%of the total membranous nephropathy,in the majority with?,?period of membranous nephropathy.Primary membranous nephropathy with IgA nephropathy accounted for 2.4%of total membranous nephropathy.5.In the study of primary membranous nephropathy patients with renal arteriolar sclerosis,interlobular arteries,arcuate hardening of the arteries is higher,the proportion of this research shows that the renal vascular sclerosis,and C3,height,blood and blood,IgM,platelet count,blood leukocyte is negatively related with age,blood lipid,blood albumin,24 hours urinary protein quantitative correlation.Conclusion:1.The proportion of primary membranous nephropathy is gradually increasing in this region.2.Patients with primary membranous nephropathy diagnosed by nephrotomy in this region have an aging trend.3.Compared with the adult group,the elderly group in this region had less urine protein and blood albumin.4.The pathological composition of primary membranous nephropathy has changed in this region in recent years.