Renal Function Of Overweight And Obese Patients With Different Metabolic Status

Object:To analyze the ratio of renal dysfunction in overweight and obese patients with different metabolic status,so as to understand the effect of overweight and obesity on renal function in patients with different metabolic status.Methods:From april 2008 to December 2016,2 cases of type 2 diabetes mellitus and 4283 cases of type 2 diabetes in department of endocrinology were collected from Hunan People's Hospital physical examination center.There were 2879 cases and 268 cases respectively.The collection of the clinical indicators:gender,height,weight,systolic blood pressure,diastolic blood pressure,duration,collection of biochemical indicators:alanine aminotransferase,triglyceride,total cholesterol,high density lipoprotein,low density lipoprotein,blood glucose,creatinine,uric acid and white blood cell count,urine protein/urine creatinine,glycosylated hemoglobin.Overweight and obesity in 2016 by the American Association of Clinical Endocrinologists(American Association of Clinical Endocrinologists,AACE)combined with the 2016 China expert consensus statement on the diagnosis of obesity,overweight and obesity diagnostic criteria:BMI = 25kg/m2;metabolic syndrome(metabolic syndrome MS)the diagnostic criteria of the National Cholesterol Education Program(the National Cholesterol Education Programe,NCEP)in adult group.The third report(Adult Treatment Panel III,ATP-III)on the definition of metabolic syndrome.The ATP-III standard was also used in the diagnosis of overweight and obesity with metabolic abnormalities.The diagnostic criteria for diabetic nephropathy(Diabetic Nephropathy,DN):urinary microalbumin/urinary creatinine>30mg/g.Chronic kidney disease(Chronic Kidney,Disease,CKD)by staging staging methods of the National Kidney Foundation K/DOQI:CKD1:eGFR?90ml/(min,1.73m2),CKD2:60ml/(min,1.73m2)CeGFR<90ml/(min,1.73m2),CKD3:30ml/(min,1.73m2)?eGFR<60ml/(min,1.73m2),CKD4:eGFR?30ml/(min,1.73m2).According to the Cockcroft-Gault formula for calculation of glomerular filtration rate(eGFR)=(140-age)*body weight(kg)]/[0.818*Scr(umol/L)],according to the calculation results of women*0.85.The difference of renal function between overweight and obesity patients with different metabolic status was compared with those of non obese normal metabolism group.Result:1?Compared with the non overweight group,the risk of renal dysfunction in the MHO group was reduced,the OR value was 0.21,P<0.05;the risk of renal dysfunction in the overweight and obese metabolic syndrome group did not increase,P>0.05;the risk of renal dysfunction in the non overweight and obese metabolic syndrome group was increased,the value of OR was 1.78,and P<0.05.2?The risk of renal dysfunction in non overweight and obese type 2 diabetes group was higher than(OR value 1.576,P<0.05)non o'verweight and obese type 2 diabetes group and non overweight obesity metabolic group.3?The risk of proteinuria increased in overweight and obese patients with type 2 diabetes than in non overweight and obese groups(OR 3.011,P<0.05).Conclusion:from normal metabolism to MS to type 2 diabetes,the risk of renal dysfunction in overweight and obese patients is lower than that in non overweight and obese patients.However,overweight andobese patients with type 2 diabetes mellitus have an increased risk of proteinuria.Conclusion:From normal metabolism to MS to type 2 diabetes,the risk of renal dysfunction in overweight and obese patients is lower than that in non overweight and obese patients.However,overweight and obese patients with type 2 diabetes mellitus have an increased risk of proteinuria.