| BackgroundBenign Prostatic Hyperplasia(BPH)is caused by urinary frequency,urgency,and dysuria in older men under one of the most common diseases of the urinary tract symptoms,the treatment with drugs,surgery,including transurethral electrovaporization of the prostate(TUVP)is the most effective surgical treatment and one of the most classic way.However,over active bladder(OAB),such as urgency,frequent micturition and urinary incontinence,are the main problems in patients.At present studies have confirmed that the bladder is excessive activity due to excessive bladder detrusor activity,and bladder detrusor activity mainly distributed in the bladder detrusor cells of M receptor mediated by,thereby blocking the bladder detrusor on M receptor can alleviate OAB symptoms.Therefore,M receptor blockers provide a solution to prevent and treat the symptoms of bladder hyperactivity after the operation of transurethral electrovaporization of the prostate.PurposeTo explore the clinical efficacy and safety of M receptor blockers(Solifenacin Succinate Tablets)in the prevention and treatment of over active bladder(OAB)after transurethral electrovaporization of the prostate(TUVP).MethodsThe 90 patients with benign prostatic hyperplasia were selected as the study subjects,and the patients were treated with transurethral electrovaporization of the prostate,and were randomly divided into 3 groups,with 30 patients in each group.A group was given M receptor blockers(Solifenacin Succinate Tablets)treatment,postoperative day 1 to 30 days postoperatively,B group was given on the pubic symphysis bladder area hot compress physical therapy(warm water towels at 50 ?),group C do not do any processing.Compare three groups of patients with over ative bladder spasm within 7 days of placing a urinary catheter number and duration of a single bladder spasm index differences,the differences and statistical analysis of pull out the catheter for 1 day,30 days after the daily average frequency,nocturia,urgency,micturition urgency incontinence number,number of bladder spasm,maximum urine flow(Qmax),residual urine volume(PVR),the international prostate symptom score(IPSS),bladder excessive activity score(OABSS),the quality of life score(QOL).Results(1)Preoperative three sets of data between various grading,Qmax,PVR differences had no statistical significance(P > 0.05),number of bladder spasm after 7 days,and on the duration of a single bladder spasm group A lower than B and C in the two groups,and group A with group B,group A with group C data between the difference was statistically significant(P < 0.05),the difference of data between group B and group C has no statistical significance(P > 0.05).(2)Compared with the preoperative three groups of patients after pulling up the urine tube 1 day each score were lower,but Qmax are was increased,however there was no statistically significant difference is compared between three groups data(P > 0.05).In group A,the frequency of bladder spasm and the duration of single bladder spasm were lower than that in group B and group C after postoperative urinary catheter for 7 days,and the difference in the data between groups was statistically significant(P < 0.05).There was no significant difference in the number of urination and Qmax between the three groups after the removal of urinary catheter.There was no statistically significant difference between the groups(P > 0.05).Group A after pulling urine tube 1 days and 30 days the daily average frequency,nocturia,urgency,micturition urgency incontinence number,number of bladder spasm,,QOL scores,IPSS scores,OABSS scores were lower than group B,C,compare the difference between groups was statistically significant(P < 0.05),but the difference of data between group B and group C has no statistical significance(P > 0.05).(3)There was no significant difference in the maximum urine flow rate between the three groups in the 30 days after the removal of the catheter,and there was no statistically significant difference between the groups(P > 0.05).The PVR of group A was higher than that of group B and C in the 30 days after removal of the catheter,and the difference between the groups was statistically significant(P < 0.05).During treatment,the incidence of adverse reactions(dry mouth,blurred vision,acute urinary retention,etc.)of group A was 7%,and both were tolerable and selfrelieved.No serious adverse events occurred.ConclusionM receptor blockers(Solifenacin Succinate Tablets)in prevention and treatment of over active bladder after transurethral electrovaporization of the prostate disease curative effect is clear,excessive activity,fewer complications,and high safety,can be recommended for clinical use. |
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