| Objectives:The study is used to evaluate the method in the treatment for OAB by observation of overactive bladder symptom score,the quality of life index,the voiding diary and urodynamic of patients suffered with overactive bladder who were treated with bixiefenqing decoction combined with succinate acid solifenacin after transurethra resecation of prostate.Methods:Distinguishing to conform to the standards of 90 cases were randomly divided into 3 groups:the experimental group,the control guoup,the blank group.The clinical study was carried out by using the method of random digits table.To detect and record the observation index of patients who suffer from OAB after 3-6 months after operation and randomly divided into different treatment.The experimental group(bixiefenqing decoction combined with succinate acid solifenacin) and the control guoup(succinate acid solifenacin) are dertected and recoreded the observation index after treated with drugs for 4 weeks;the blank group is also dertected and recoreded the observation index after 4 weeks.Comparing and analyzing the data of OABSS,Qol,micturition diaries and urine dynamics in ever group before and after treatment,and then make a preliminary evaluation.Results:Total effective rate:The total effective rate of the experimental group and the control group was higher than that of the blank group.There were significant differences(P <0.05)comparing between experimental group(88.46%)and blank group(28.00%).There were significant differences(P <0.05) comparing between control group(74.07%)and blank group(28.00%). There were no significant differences(P>0.05) comparing between experimental group(88.46%)and control group(74.07%). The total effective rate in the experimental group was not higher than that in the control group.OABSS score:The experimental group and the control group were compared with the blank group of OABSS after treatment, and there were significant differences(P<0.05).There were significant differences(P<0.05)comparing between experimental group(4.17±2.27)and blank group(8.73±1.91).There were significant differences(P<0.05) comparing between control group(5.39±1.58)and blank group(8.73±1.91). There were significant differences(P<0.05) comparing between experimental group(4.17±2.27)and control group(5.39±1.58).Qol index:The experimental group and the control group were compared with the blank group of Qol index after treatment, and there were significant differences(P<0.05).There were significant differences(P<0.05)comparing between experimental group(2.03±0.87)and blank group(3.99±0.93).There were significant differences(P<0.05) comparing between control group(2.78±0.81)and blank group(3.99±0.93). There were significant differences(P<0.05) comparing between experimental group(2.03±0.87)and control group(2.78±0.81).Micturition diary:The experimental group and the control group were compared with the blank group after treatment, and there were significant differences(P<0.05) in 24 h micturition frequency,night urine frequency,the number of urgency in 24 h and mean urine volume.24 h micturition frequency:There were significant differences(P<0.05)comparing between experimental group(7.92±2.07)and blank group(13.17±2.36).There were significant differences(P<0.05)comparing between control group(8.65±1.82)and blank group(13.17±2.36).There were significant differences(P<0.05) comparing between experimental group(7.92±2.07)and control group(8.65±1.82).Night urine frequency:There were significant differences(P<0.05)comparing between experimental group(1.69±0.57)and blank group(3.12±0.94).There were significant differences(P<0.05) comparing between control group(1.87±0.33)and blank group(3.12±0.94). There were no significant differences(P>0.05) comparing between experimental group(1.69±0.57)and control group(1.87±0.33).24 h number of urgency:There were significant differences(P<0.05)comparing between experimental group(1.92±0.90)and blank group(3.79±1.92).There were significant differences(P<0.05) comparing between control group(2.17±0.73)and blank group(3.79±1.92). There were significant differences(P<0.05) comparing between experimental group(1.92±0.90)and control group(2.17±0.73).Mean urine volume:There were significant differences(P<0.05)comparing between experimental group(164.37±30.06)and blank group(84.27±26.83).There were significant differences(P<0.05)comparing between control group(152.51±24.55)and blank group(84.27±26.83). There were significant differences(P<0.05) comparing between experimental group(164.37±30.06)and control group(152.51±24.55).The experimental group is better than the control group in improving24 h micturition frequency and the number of urgency in 24 h,but there was no significant difference in the improvement of the number of night urine and 24 h urine volume.Urinary dynamics:The experimental group and the control group were compared with the blank group in terms of the relevant indicators of the flow dynamics after treatment, and there were significant differences(P<0.05) of first urine bladder pressure P/bladder capacity V and bladder systolic pressure≥15cm H2 o frequency N.The first urine bladder pressure P/bladder capacity V,there were significant differences(P<0.05)comparing between experimental group(0.78±0.19)and blank group(1.64±0.21).There were significant differences(P<0.05) comparing between control group(0.98±0.14)and blank group(1.64±0.21). There were significant differences(P<0.05)comparing between experimental group(0.78±0.19)and control group(0.98±0.14).The bladder systolic pressure≥15cm H2 o frequency N:there were significant differences(P<0.05)comparing between experimental group(1.17±0.23)and blank group(2.94±0.36).There were significant differences(P<0.05) comparing between control group(1.74±0.18)and blank group(2.94±0.36). There were no significant differences(P>0.05)comparing between experimental group(1.17±0.23)and control group(1.74±0.18).The incidence of adverse reactions:The incidence of adverse reactions in the experiment group and the control group were higher than that in the blank group.There were significant differences(P<0.05)comparing between experimental group19.23%)and blank group(3.84%).There were significant differences(P<0.05) comparing between control group(24.14%)and blank group(3.84%). There were no significant differences(P>0.05) comparing between experimental group(19.23%)and control group(24.14%).Conclusion:The test group can reduce the lower burner vacuity cold type overactive bladder in OABSS, Qol index,and improve lower burner vacuity cold symptoms,reduce 24 h micturition frequency and night urine frequency and the number of urgency in 24 h,increase mean urine volume,and no serious adverse reactions and side effects were found during the treatment period,and the overall effect is better than the simple oral western medicine treatment.Bixiefenqing decoction combined with solifenacin can be effective in the treatment of OAB and can improve the lower burner vacuity cold type symptoms and the incidence of adverse reactions was low,which provide another way of thinking for the clinical treatment of the disease. |
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