| 【Objective】 To explore the relationship between uric acid and bone mineral density(BMD)and bone metabolism markers(BTMs)in type 2 diabetic patients.【Methods】 We enrolled 719 hospitalized patients with T2 DM into the study,among which 354 were male,average age(58.76±12.20)years old,and 359 were female,average age(62.71±10.83)years old.We randomly chose 100 healthy individuals who accepted health examination during the same period as the contrast.53 were male among them,average age(58.63±8.47)years old,and 47 were female,average age(61.15±9.10)years old.In patients with type 2 diabetes and 100 normal physical examination in sex,comparisons among groups of serum uric acid levels and bone mineral density and bone metabolic markers index differences,Pearson correlation analysis,further understanding of uric acid and the relationship between bone mineral density and bone metabolism markers.In addition to patients with type 2 diabetes,according to the American rheumatism association in 2016 China gout guidelines,divided the patients into normal uric acid(NUA)group 593 cases,high uric acid(HUA)group 120 examples,analyze its correlation with bone mineral density and bone metabolism.Multivariate stepwise regression analysis was performed to understand the relationship between bone metabolism markers and bone density.【Results】⑴ There was no significant difference in age,SUA,BMI,SCr,N-OC,CTX,PINP,AST,ALT between normal control group and type 2 diabete group;TG and FPG were significantly higher than those in normal control group.⑵ In type 2 diabetes group,male SUA and L1-4,Ward,s,femoral neck and femur were all higher than female,while N-OC,PINP and CTX were all lower than female group.⑶ N-OC and BMD of L1-4,femoral neck and femur of the HUA group were significantly higher than that in the NUA group.⑷ In type 2 diabetes group,women,s SUA with N-OC and BMD of the L1-4 were positively correlated,r value is 0.153,0.124(P < 0.05),the male,s SUA with N-OC and BMD of L1-4,femoral neck were positively correlated,r value was 0.147,0.156,0.113(P<0.05);SUA of both male and female in normal control group positively correlated with N-OC,r value was 0.119,0.125(P>0.05).⑸ The BMD of the male of type 2 diabetes mellitus was not related to N-OC and PINP(P>0 0.05),and the BMD of L1-4,femoral neck and femur was negatively correlated with CTX.Among women,the BMD of each part was not related to PINP(P>0.05),BMD of femoral neck and femur was negatively correlated with N-OC(P<0.05),BMD of L1-4 and Ward,s was negatively correlated with CTX(P<0.05).【Conclusion】 Elevated serum uric acid may be a protective factor for maintaining bone mass in patients with type 2 diabetes.In the diagnosis and treatment of osteoporosis with type 2 diabetes,it is important to pay attention to the monitoring level of CTX. |
