The Resting State FMRI Study Of Brain Function Changes In Chronic Alcohol Exposure Of Rhesus Monkey

Objective To establish a rhesus monkey chronic alcohol exposure model and use resting-state functional magnetic resonance(rs-fMRI)to detect the changes of resting brain activity in rhesus monkeys with chronic alcohol exposure.Methods Seven chronic rhesus monkey models of chronic alcohol exposure were established.The monkey received multi-phase resting fMRI scanning,P0 before drinking,P1 at the end of the induction period for 1 month,P2 for 3 months Period,and P3 for 6 months for the P3 period.Both fALFF and Reho were used to analyze the resting state data,and the different brain areas were compared.Results 1 Brain areas with great difference in fALFF1.1 For overall comparison(P0-P1-P2-P3 phase),the brain regions with great difference of fALFF values include the left upper occipital gyrus,the left temporal lobe fusiform gyrus,left cerebellar vermis,left pons(P<0.005).1.2 Compared with P0 phase,the fALFF value in the following brain regions decreased,including the right suboccipital gyrus,right orbital gyrus,right islets,left wedge leaves,left central canal,left superior frontal gyrus in P1 phase(P<0.005),and those regions increased,including left superior temporal gyrus,left inferior temporal gyrus,left anterior gyrus,right amygdala,right parietal parietal lobule,and right cerebellar vermis(P<0.005).1.3 Compared with the P0,the fALFF value in the following brain regions decreased,including the right orbital,right island,right pontine,left superior frontal gyrus,left anterior wedge leaf in P2 phase(P<0.005),but none increased.1.4 Compared with the P0,the fALFF value in the following brain regions decreased,including the left cerebellar hemispheres in P3 period(P<0.005),and those brain regions increased which include the right top of the leaflets,the right upper temporal gyration,the right middle occipital gyrus,the right cerebellar vermis Department,left superior temporal gyrus,left temporal gyrus,left superior occipital gyrus,left cerebellar hemisphere(P<0.005).1.5 Compared with P1,there are following brain areas decreased,which including left cerebellar vermis,left temporal fusiform gyrus,left temporal gyrus,left inferior occipital gyrus,right superior parietal lobule in P2 period(P<0.005)and those increased,including the left top of the leaflets,the left frontal gyrus,left frontal gyrus,left cerebellar hemisphere,right cerebellar vermis,right temporal gyrus,right orbital gyrus,the right arm,Right cerebellar hemisphere(P<0.005).1.6 Compared with the P1,the following brain regions decreased,including left temporal fusiform gyrus,right central back,right wedge,right middle back,right brain stem in P3 period(P<0.005),and those increased,which include the left frontal gyrus,the left orbital gyrus,the left basal ganglia,the left cerebellar hemisphere,the right cerebellar vermis,the right temporal gyrus,the right orbital gyrus,the right occipital gyrus,the right lateral gyrus Anterior cingulate back(P<0.005).1.7 Compared with the P2 period,the following brain areas decreased,including the left middle occipital gyrus,the left middle temporal gyrus in P3 period(P<0.005),but no increased.2 Brain areas with great difference in Reho2.1 For overall comparison(P0-P1-P2-P3 phase),the brain areas with great difference include left central front gyrus,left orbital gyrus,left middle occipital gyrus,left middle temporal gyrus,Left pontine(P<0.005).2.2 Compared with the P0,the following brain regions decreased,including the right temporal back,the right suboccipital gyrus,the left central anterior gyrus,left frontal gyrus,left orbital gyrus,left temporal gyrus,left Occipital superior gyrus,left anterior cingulate gyral,upper left frontal gyrus in P1 phase(P<0.005),and those increased,which include the left central anterior gyrus,the left wedge leaf,the left upper occipital gyrus,the left cerebellar vermis,left brain The right middle frontal gyrus,right parietal lobe,right basal ganglia,right superior temporal gyrus(P<0.005).2.3 Compared with the P0,the following brain areas reduced,including the right central back,the right top of the leaflets,the left frontal gyrus in P2 phase(P<0.005),and those increased,including the right upper frontal gyrus,right temporal Middle back(P<0.005).2.4 Compared with the P0,the following brain regions decreased,including the left orbital gyrus,left upper quadrant,right upper occipital gyrus,right cerebellar hemisphere,right cerebellar subforamen in P3 period(P<0.005),and those increased,including left superior occipital gyrus,left superior quadrant,right superior temporal gyrus,right temporal gyrus,right posterior cingulate gyrus,right inferior occipital gyrus,right lateral pons(P<0.005).2.5 Compared with the P1,the following brain areas reduced,including the left central back,the left suboccipital gyrus,the right central ditch,the right upper frontal gyrus,the right basal ganglia,right middle temporal gyrus,right cerebellum The hemisphere in P2 period(P<0.005),and those increased,including left central anterior gyrus,left anterior cingulate gyrus,left orbital gyrus,left cerebellar hemisphere,right temporal gyrus,right parietal lobe,right lateral cusp,right cerebellar vermis(P<0.005).2.6 Compared with the P1 phase,the following brain regions decreased including the left central anterior back,the left suboccipital gyrus,the right parietal lobe in P3(P<0.005),and those increased,which include left orbital gyrus,left cerebellar hemisphere,right superior temporal gyrus(P<0.005).2.7 Compared with P2 period,the following brain areas decreased including the left orbital gyrus,the left posterior cingulate gyrus,the right posterior cingulate gyrus,the right inferior occipital gyrus,the right cerebellar in P3 period(P<0.005),and those increased,which include left central anterior commissure,left lateral arm,right basal ganglia,and right inferior temporal gyrus(P<0.005).Conclusion It is feasible to establish Rhesus chronic alcohol exposure model under free management.Rhesus monkey under chronic alcohol exposure demonstrate great dynamic changes in brain function involved cognitive function,audiovisual,emotional memory,somatosensory and limbic system.Overall,it has the trend of left lateralization.The frontal lobe has little change after long-term exposure.