A Preliminary Study On The Effects Of Acute Ethanol Ingestion On Healthy Rhesus Brain

Objective To evaluate the acute effects of alcohol on healthy Rhesus brain with resting- state fMRI.Methods Rhesus(M, n = 7), no history of exposure to alcohol. seven healthy Rhesus were studied by resting-state fMRI before and 10,28,46 minute after initiation of acute alcohol administration(0.44g/kg),Images were processed by using Data Processing Assistant for Resting-State fMRI(DPASF) and SPM12.fALFF and Reho of the four groups were acquired.Results 1. 1. Brain areas with significant difference of fALFF among four groups were as follows:right postcentral gyrus, right insula, cerebellum, the left parahippocampal gyrus, bilateral inferior frontal gyrus, right occipital, the left supramarginal gyrus, precuneus.(all P<0.05).2. Brain areas with decreased fALFF after initiation of acute alcohol administration included bilateral superior frontal gyrus, right inferior frontal gyrus,right fusiform gyrus and right angular gyrus, the bilateral superior temporal gyrus,right occipital,left lateral sulcus,the left postcentral gyrus, the left cuneus, left thalamus, the left insula, anterior cingulate(all P<0.05).3. Brain areas with increased fALFF after initiation of acute alcohol administration included right inferior frontal gyrus,right middle temporal gyrus(all P<0.05).4. Brain areas with significant difference of Reho among four groups were as follows:bilateral inferior frontal gyrus, the left caudate nucleus, the right superior temporal gyrus and right parahippocampal gyrus and right occipital gyrus, the left middle temporal gyrus, right precuneus and midbrain(all P<0.05).5. Brain areas with decreased Reho after initiation of acute alcohol administration were right superior frontal gyrus, cuneus, left occipital(all P<0.01).6. Brain areas with increased Reho after initiation of acute alcohol administration were right inferior frontal gyrus, the posterior cingulate, the right precentral gyrus, right precuneus, right side of the corpus callosum(all P<0.01).Conclusion Acute effects of alcohol on brain function in rhesus monkeys is wide and mainly appeared as inhibition,which, mainly involving default mode network,.the reward and emotional processing system and visual cortex. Primate model have great reference value for clinical drug research.