| Objective To evaluate the acute effect of low levels of alcohol on the brain function based on resting-state functional MRI.Methods Seventeen healthy male volunteers before and after alcohol were examined by MRI in the resting state.Both groups were examined by echo planner imaging(EPI) and spoiled gradient recalled acquisition in steady state.(3D-FSPGR). Images were processed by using the Data Processing Assistant for Resting-State f MRI(DPASF).Amplitude of low frequency fluctuations(f ALFF), regional homogeneity(Re Ho) and functional connectivity(FC) of eleven brain networks in both groups were obtained. SPM12 and SPSS13.0 software were used to analyse the difference between the two groups.Results 1.Compared with pre-alcohol, post-alcohol f ALFF was lower in right angular gyrus,right orbital superior frontal gyrus,right superior medial frontal gyrus( P<0.001);Post-alcohol f ALFF was higher in right superior temporal gyrus,right Rolando area,right superior temporal pole(P<0.001).2.Compared with pre-alcohol, post-alcohol Re Ho was lower in bilateral orbital frontal gyrus,bilateral posterior cingulate gyrus,bilateral middle occipital gyrus,right angular,right precuneus,left middle frontal and left middle temporal gyrus(P<0.01);Post-alcohol Re Ho was higher in left supplementary motor area,left superior frontal gyrus,left temporal pole superior temporal gyrus,left fusiform gyrus,right superior temporal gyrus,left middle temporal gyrus,bilateral anterior cingulate gyrus,right inferior occipital gyrus(P<0.01).3.The change of the FC in the eleven network between post-alcohol group and pre-alcohol group.3.1 Compared with pre-alcohol, post-alcohol FC of auditory network(AN) were higher in bilateral postcentral gyrus,bilateral middle temporal gyrus,bilateral inferior temporal gyrus,bilateral orbital inferior frontal,right superior temporal gyrus,right thalamus,left inferior parietal,left middle occipital gyrus,left temporal pole superior temporal gyrus,left Rolando area,left orbital middle frontal gyrus(P<0.01);post-alcohol FC of AN were lower in right cingulate gyrus,vermis(Ⅰ-Ⅲ)(P<0.01).3.2 Compared with pre-alcohol, post-alcohol FC of basal ganglia network(BGN) were higher in bilateral thalamus,bilateral putamen,bilateral insular lobe,left precuneus,left posterior cingulate gyrus,right inferior temporal gyrus,right hippocampus,right caudatum(P<0.01);post-alcohol FC of BGN were lower in right precuneus,right superior parietal,right supplementary motor area,right superior medial frontal gyrus,right middle cingulate gyrus,right middle frontal gyrus(P<0.01).3.3 Compared with pre-alcohol, post-alcohol FC of dorsal default mode network(DDMN) were higher in bilateral supplementary motor area,bilateral inferior frontal gyrus,bilateral inferior temporal gyrus,left superior frontal gyrus,left middle frontal gyrus,left superior temporal gyrus,left middle occipital gyrus,right precentral gyrus,right insular lobe,right middle temporal gyrus(P<0.01);post-alcohol FC of DDMN were lower in bilateral middle cingulate gyrus,left posterior cingulate gyrus(P<0.01).3.4 Compared with pre-alcohol, post-alcohol FC of emotional memory network(EMN) were higher in bilateral caudatum,bilateral pallidum,bilateral putamen,bilateral insular lobe,left superior temporal gyrus,left fusiform gyrus,left lingualis gyrus,left inferior temporal gyrus,left parahippocampal gyrus,left amygdala,right posterior cingulate gyrus,right angular gyrus,right precuneus(P<0.01).3.5 Compared with pre-alcohol, post-alcohol FC of left executive control network(LECN) were higher in bilateral orbital medial frontal gyrus,bilateral orbital frontal gyrus,bilateral olfactory cortex,left middle occipital gyrus,left inferior occipital gyrus,left superior medial frontal,left anterior cingulate gyrus,left Rolando area,left supra marginal,left superior temporal gyrus,right middle temporal gyrus,right inferior temporal gyrus,right insular lobe,right postcentral gyrus,right fusiform gyrus(P<0.01);post-alcohol FC of LECN were lower in bilateral inferior frontal gyrus,right middle frontal gyrus(P<0.01).3.6 Compared with pre-alcohol, post-alcohol FC of language network(LN) were higher in bilateral superior temporal gyrus,bilateral inferior occipital gyrus,left hippocampus,left lingualis gyrus,left Rolando area,left supra marginal,left superior frontal gyrus,left middle frontal gyrus,left orbital superior frontal,left orbital middle frontal gyrus,left middle occipital gyrus,right inferior temporal gyrus,right superior occipital gyrus,right orbital inferior frontal,right fusiform gyrus(P<0.01);post-alcohol FC of LN was lower in right middle cingulate gyrus(P<0.01).3.7 Compared with pre-alcohol, post-alcohol FC of primary visual network(PVN) were higher in bilateral caudatum,bilateral insular lobe,bilateral inferior temporal gyrus,bilateral calcarine,left temporal pole superior temporal gyrus,right cerebelum crus( Ⅱ),right middle temporal gyrus,right fusiform gyrus,right hippocampus,right lingualis gyrus(P<0.01);post-alcohol FC of PVN was lower in right supplementary motor area(P<0.01).3.8 Compared with pre-alcohol, post-alcohol FC of right executive control network(RECN) were higher in left superior frontal gyrus,left supplementary motor area,left fusiform gyrus,left orbital inferior frontal gyrus,left middle temporal gyrus,left rectus gyrus,right precentral gyrus,right postcentral gyrus,right insular lobe(P<0.01).3.9 Compared with pre-alcohol, post-alcohol FC of sensorimotor network(SMN)were higher in bilateral orbital inferior frontal gyrus,bilateral temporal pole superior temporal gyrus,bilateral supplementary motor area,bilateral superior frontal gyrus,bilateral inferior temporal gyrus,bilateral fusiform gyrus,left paracentral lobule,left middle cingulate gyrus,right middle temporal gyrus,right temporal pole superior temporal gyrus,right postcentral gyrus(P<0.01);post-alcohol FC of SMN were lower in bilateral middle frontal gyrus,left thalamus,left caudatum,left inferior frontal gyrus,right superior frontal gyrus(P<0.01).3.10 Compared with pre-alcohol, post-alcohol FC of ventral default mode network(VDMN) were higher in bilateral inferior temporal gyrus,bilateral fusiform gyrus,bilateral postcentral gyrus,left hippocampus,left lingualis gyrus,left Rolando area,left insular lobe,left middle occipital gyrus,left parietal lobe,right parahippocampus,right temporal pole middle temporal gyrus,right superior temporal gyrus,right middle temporal gyrus(P<0.01);post-alcohol FC of VDMN were lower in left cerebelum crus(Ⅸ),right middle frontal gyrus,right inferior frontal gyrus(P<0.01).3.11 Compared with pre-alcohol, post-alcohol FC of visuospatial network(VPN) were higher in bilateral insular lobe,left Rolando area,left supra marginal gyrus,left supplementary motor area,left superior frontal gyrus,left temporal pole superior temporal gyrus,left orbital superior frontal gyrus,left middle temporal gyrus,right postcentral gyrus,right orbital inferior frontal gyrus,right precentral gyrus,right inferior occipital gyrus(P<0.01).Conclusion Alcohol drinking in healthy subject can change the regional activity of the brain and the function connection between different brain regions,which will influence the function of memory,control, execution and so on. |
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