Research And Design Of Wireless High-voltage Deep Brain Stimulator

Deep Brain Stimulation(DBS)has been clinically proven to be effective in the treatment of neurological diseases such as Parkinson's disease.DBS with wireless energy and data transmission can overcome the shortcomings of traditional primary battery-powered DBS,such as short service cycle and large space occupation.And studies have shown that high-density electrical stimulation has a better therapeutic effect on nervous system diseases.In order to achieve high-density electrical stimulation,more stimulus channels are needed.The diameter of the stimulus electrode implanted into human body is relatively small,and its impedance will be relatively large.In order to obtain a stimulation current that achieves a therapeutic effect,a higher stimulation voltage is required.Therefore,it is of great significance to design a high-voltage DBS with wireless energy and data transmission.Based on the investigation and analysis of the development of implantable stimulator,a high-voltage DBS with wireless energy and data transmission is proposed in this thesis.The proposed wireless high-voltage DBS uses inductively coupled energy transmission and ASK data modulation to achieve stable transmission of energy and data.The external capacitor-less LDO with high power supply rejection ratio and current source based wireless high-voltage transmission structures provide ±1.5V DC low voltage and ± 10 V DC high voltage,respectively.The closed-loop control of energy is realized by the back-forward telemetry circuit.Data and clock recovery circuit realizes the recovery of control signal,and the conversion of control signal from low voltage to high voltage is realized by the level shift.In order to realize the controllable charging of storage capacitor by±10V DC high voltage,the voltage attenuator formed by series capacitors attenuates the voltage of storage capacitor from high voltage range to low voltage range.Moreover,the discharge capacitor selection circuit and the discharge electrode selection circuit realize the selection of the storage capacitor discharge logarithm and the discharge channel,respectively.The charge balancing circuit achieves the balance of the amount of positive and negative charges injected.The circuit is designed under TSMC 0.18?m high voltage CMOS technology and simulated by Cadence-Spectre.From the simulation results,it can be seen that the proposed wireless high-voltage DBS can provide exponential attenuation stimulation with adjustable amplitude,adjustable pulse width,adjustable sequence and interval of positive and negative voltage stimulation to nerve tissue.And the positive voltagestimulation can reach 10 V,the negative voltage stimulation can reach-10 V.The proposed wireless high-voltage DBS realizes the function of high-voltage stimulation and meets the needs of high-density stimulation.