Research Process And Quality Standard Of Qingxue Jiedu Mixture

The "Qingxue Jiedu" prescription is mainly composed of honeysuckle,forsythia,scutellaria,red peony,habitat,peony bark,Scrophulariaceae,angelica,poria cocos,licorice ten flavor medicine.Based on the combination of long-term clinical experience and large data comparison of patient treatment,the experience formula is mainly composed of drugs for clearing heat and detoxifying and relieving dampness and itching.It has significant effects on skin redness and itching caused by dampness and heat.Therapeutic effect is mainly used to treat skin itching caused by damp heat.In order to better serve patients and the people,reduce the dosage,enhance the efficacy of drugs,expand industrial production,and conduct systematic and comprehensive research and exploration on this party.Under the condition of keeping the original prescription effect unchanged,the party was redeveloped.In order to inherit the characteristics of traditional Chinese medicine and save production time,it is suitable for large-scale mechanized production.Therefore,this recipe was investigated and finally prepared into a mixture.At the same time,in order to further strengthen quality management,it inspects its quality standards,fingerprints,preliminary stability and other aspects to make the quality reliable and controllable,and the safe use of drugs also provides a certain theoretical basis for the next declaration of preparations.In terms of extraction technology,L9(34)orthogonal test design methodwas used to investigate the extraction time,extraction times and water consumption of the prescription.The dry paste yield,chlorogenic acid,forsythiaside A,and baicalin were The main reference index,the most reasonable process method is selected by weighted comprehensive score;combined with the percentage,relative density,and pH of the added auxiliary materials,the best molding process is selected;finally,the three batches of pilot scale-up tests are investigated.The data research results show that the process is stable and feasible,that is,the most reasonable extraction process is to add 12 times the amount of water,soak for 1.5h,extract 3 times,decoction for 1h each time,shake and mix to stand for 12 h,add auxiliary materials,bottle.In terms of quality standard research,the The-Layer chormatography(TLC)statutory identification is adopted for the monarch and chemist in the prescription;High Perfmance Liquid Chromatagraphy(HPLC)method was used to quantitatively analyze the content of chlorogenic acid,forsythiaside A,and baicalin in this formula,and the prescription quality standard was formulated,and the "Fingerprint of Qingxuejiedu Mixture" was also established.At the same time,the stability of the Qingxuejiedu mixture was tested,and three factors(high temperature,high humidity,and strong light irradiation)and accelerated experimental investigation were conducted on the mixture with the samples of the pilot test.The preliminary stability test results show that the various indicators and the content of the main active ingredients of Qingxuejiedu mixture meet the relevant regulations under the draft standard,so it can be preliminarily concluded that there is no significant change in Qingxuejiedu mixture within 6 months.In summary,this subject mainly investigated the extraction process,quality standards,fingerprints,and stability of Qingxue Jiedu Mixture,screened the most reasonable extraction process of Qingxue Jiedu Mixture,and comprehensively carried out quality standards The improvement guarantees the stability of mass production quality and lays a solid foundation for the safe and effective preparation.