Study On The Generation Of Glow Plasma And Surface Modification Of Artificial Blood Vessels

At present,the clinical application of small-diameter artificial blood vessels(inner diameter 6mm)is seriously limited due to the poor anticoagulant energy on the surface.Atmospheric pressure glow discharge plasma has the advantages of uniform discharge form,moderate plasma density,low power consumption,clean,efficient,pollution-free and abundant active particles,so it becomes an ideal method to solve this problem.The aim of this paper is to propose a plasma generation method of atmospheric pressure air glow discharge for the tubular structure of artificial blood vessels and to explore its modification effect on the surface of artificial blood vessels.Firstly,the discharge characteristics and influencing factors of contact electrode are analyzed.Combined with electric field simulation and discharge experiment a helical electrode structure is proposed on the basis of cross electrode.The influence factors of this electrode structure to generate glow discharge in atmospheric air were discussed,including electrode diameter,screw distance,insulation thickness,dielectric barrier mode and electrode material.Finally,a 3D cover glow plasma was successfully generated,and the optimal electrode structure parameters were obtained.Secondly,in order to generate plasma in the inner wall of artificial blood vessels and obtain better surface modification effect,the structure of thimble tripotential suspended electrode was obtained by optimizing the spiral electrode.The effects of different air gaps and different discharge voltages on the formation of penetrating plasma discharge in air gaps were investigated,and the best parameters for the formation of penetrating plasma discharge in air gaps were obtained.Finally,the modified materials were characterized by water contact Angle detection,The results showed that the modified effect of the thimble three-potential electrode was better than that of the tubular sample treated with spiral electrode.Finally,plasma grafting was used to graft heparin biomacromolecules into the inner wall of artificial blood vessels,so as to further explore the modification effect of artificial blood vessels with different plasma treatment time.Detection by water contact Angle,The hydrophilicity of artificial blood vessels under heparin,polyethylene glycol,plasma direct treatment,plasma grafting treatment and different treatment time were compared and analyzed;The surface morphology of artificial blood vessel after grafting was analyzed by SEM.The surface anticoagulant changes of artificial blood vessels after plasma grafting were further analyzed by platelet adhesion experiment.The results showed that when the plasma treatment time was 40s,the platelet adhesion was the least,the hydrophilic enhancement rate reached 51%,and the anticoagulant of artificial blood vessel was greatly improved.58 images,12 tables,101 references.