A Multiscale Analysis Of Tissue Engineering Bone Scaffolds And Its Preparation Technics From The Perspectives Of Macroscale To Microsale

This article uses piston deposition extrusion rapid prototyping technology to prepare scaffolds in Bone Tissue Engineering.Because the mixed materials affect the mechanical properties of the bone scaffolds,and a large number of experiments are required to set the process parameters in the process of preparing the bone scaffolds.In order to improve the scaffolds in Bone Tissue Engineering to control the shape and control preparation,the amount of experimental materials in the experimental process is reduced and the preparation process is avoided.The randomness of the parameters set by the micro-mesoscale multi-scale simulation analysis,simulated calculation of mechanical properties of mixed materials and fluid distribution state,to provide a theoretical basis for the preparation of bone scaffolds.The preparation of bone scaffolds mainly uses biomaterials such as hydroxyapatite,polyvinyl alcohol and silk fibroin.At the micro-mesoscopic level,the mechanical properties parameters of Hydroxyapatite,polyvinyl alcohol,and silk fibroin were simulated by the molecular dynamics simulation software Materials Studio.It was proved that the three interactions have good adhesion and the mechanical properties of the mixed material can satisfy the bones.The requirements of the organization and the feasibility of the hybrid mechanical properties of many other materials can be demonstrated through simulation analysis at the same time,thereby reducing the experimental amount of material diversity in the experimental process.At the macro level,the FLUENT software simulates the uniaxial and coaxial flow channels,considers the swell effect of the fluid,simulates the fluid distribution,analyzes the fluid distribution in the flow channel at different temperatures and speeds,and simulates the parameters through preparation parameters.To achieve the matching of the speed of the nozzle device and the speed of the moving platform,a bone stent with a neat wire and controllable pores was prepared.To improve the 3D printing device,the optimization of the nozzle device,the addition of the heating device and the refrigeration device,in order to ensure thequality of the stent,three kinds of biomaterials,hydroxyapatite,polyvinyl alcohol and silk fibroin,were used to analyze the viscosity and swell effect of the material.The effects of different heights,speeds,and temperatures on the molding of the stent during different mixing ratios and preparations were selected to optimize the preparation parameters and to efficiently complete the preparation of the bone scaffold.Finally,the material properties and biological properties of the stent were analyzed to verify that the mechanical properties and porosity of the scaffold satisfied the bone requirements.After 12 weeks of implantation in New Zealand white rabbits,it was observed that the preparation of the biomaterial bone scaffold effectively promoted the growth of the bone injury site.