Clinical Characteristics Of Colorectal Polyps And Colorectal Cancer Signaling Pathways, Gene Analysis

Colorectal cancer is the world's third highest incidence and the fourth highest mortality cancer.With the improvement of living standard and diagnosis and treatment technology,the incidence of colorectal cancer is increasing.At present,the view of canceration course of colorectal cancer is that the normal mucosa passes through mucosal protrusion,small adenomatous polyp,large adenoma,high-grade tumor and finally to malignant tumor.The study of polyps,especially the study of adenomas,is of great significance for early cancer screening and cancer prevention.Objective:To analyze the age,location and pathological types of colorectal polyps.Methods:This study was a retrospective analysis of clinical data of hospitalized cases,save the data management system and system by gastroscopy in our hospital collected from January 2013 to December 2015,the retrospective review of 2273 cases of enteroscopy positive patients,age and location,polyps and pathological examination results of polyp properties and other aspects of statistics.At the same time,14 cases of special type polyps and filiform polyposiss were found,and their admission complaints,stool status,past operative history,pathological findings and location were descriptive statistics.Result: Of the 2273 patients with colorectal polyps,1245(54.8%)were aged over 60,887(39%)between 45-59 years old.141(6.2%)young people were born under the age of 45.Among 925 cases of non neoplastic polyps,420(45.4%)cases occurred at 45-59 years old,419(45.3%)cases occurred above 60 years old,1348 cases of tumor polyps,826(61.3%)occurred in the elderly over the age of 826,and 60(60)occurred in middle-aged middle-aged people.55(4.1%)young people were born under the age of 45.Adenoma tubular adenoma in 475 cases,tubular adenocarcinoma in 65 cases,the rate of canceration is 8.3%,villous tubular adenoma in 362 cases,villous tubular adenocarcinoma 19 cases,canceration rate is 5%,5 cases of villous adenoma,and 3 cases of villous adenocarcinoma,the rate of canceration is 37.5%.The difference of the rate of canceration was statistically significant(P=0.001).There was no difference between the canceration rate of tubular adenoma and villous tubular adenoma(P=0.053),and these two were different from the canceration of cashmere adenoma(P=0.004/0.000).The canceration rate was the highest in liver:58.5%(20/34),followed by the ileocecal valve 52.8%(19/36)was 45.6%(62/136),no difference between the three canceration rate(P=0.341).There was significant difference between carcinoma of rectum and sigmoid colon,ascending colon three rate(P=0.000).Age:14 cases of FP patients,age 84 years old,the youngest 49 years old,the average age(62 + 9.9);gender:6 males,8 females;the ileocecal valve in 6 cases(42.9%),ascending colon,transverse colon,descending colon,sigmoid colon,2 cases(14.3%);9 cases of history have a history of surgery(64.3%),of which 6 history of appendectomy(42.9%)cases,colonic polyp cutting,cholecystectomy,resection of uterine leiomyoma in each one,no special 5(35.7%)cases.There were 7 cases of diarrhea or defecation,1 cases of constipation and 6 cases of normal stool.There were 11 cases of pathological results,5 cases of inflammatory polyp,3 cases of inflammatory polyp,localized tubular adenoma,2 tubular adenoma,and 1 tubular villous adenoma.Discussion:the occurrence of polyps and adenocarcinoma is associated with age,and the polypoid adenoma-adenocarcinoma path is time dependent.Polyps are the initial stage,which is more common in people under 60 years of age.The age of the adenoma is the good age of the adenoma when the age reaches 60 years.There is no obvious correlation between age and pathological type.The canceration rate of different pathological types is different,and villous adenoma has the highest tendency to change malignancy.In addition,different parts of the polyp canceration tendency is different,and the hepatic flexure of the ileocecal,ascending colon polyps,canceration of maximum likelihood.The possibility of polypoid precancerous age and right colon polyp carcinogenesis may be due to long-term chronic inflammatory reaction.filiform polyposiss can confirm the stimulation of long-term inflammation,which can lead to intestinal mucosal hyperplasia,but not necessarily cancer.Like obesity,diabetes and other metabolic factors,long-term inflammatory response can lead to the proliferation of mucous membrane.