A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Evaluated The Safety And Efficacy Of Chuanxiong Qingnao Granules

Backgroud Migraine is a chronic paroxysmal neurological disease characteriesd by heavy head pain and neurological symptoms,such as photophobia,nausea.The effect of drug therapy(eg,triptans),including prevention and acute treatment,is available but not stable,and most of them have obvious side-effect.Traditional Chinese Medicine have a unique advantage.Objective To observe the clinical effectiveness of Chuanxiong qingnao particles contrasting with the placeboMethods Chuanxiong qingnao particles was given to the experimental group 1 bag each time,3 times a day for 1 month.Similarly,the treatment group was given a placebo.Both of the two group should be reviewed two months later after taking the medicine.Results The clinical study included 224 cases,which contained 112 cases in the treatment group.The headache episodes significantly reduced during the treatment,and after one month,headache degree(NRS score)also obviously went down.Some of patients could end up the headache breaking out by having the chuanxiong qingnao particies immediately.The safety could be guaranteed by contrasting the blood routine examination and hepatorenal function between the two groups.Conclusion Chuanxiong qingnao particles can significantly reduce the onset of migranine and the times of migraine attacks and improve the living quality.The security could be promoted in clinical.