| Objective:1.To observe the therapeutic efficiency of 'prescription of ding xiang zhi tong' acupoint application on the treatment of cancerous abdominal pain.2.To evaluate the safety of'prescription of ding xiang zhi tong' acupoint application on the treatment of cancerous abdominal pain.Methods:A prospective,randomized,double-blind,placebo-controlled clinical trial was used in this study.Fifty patients who met the inclusion criteria were randomized to the experimental and placebo groups,each with 25 patients.The treatment group use the basic treatment and'prescription of ding xiang zhi tong ' acupoint application,while placebo group use the basic treatment and placebo acupoint application,treatment for 7 days,after the end of treatment the observation lasted for 3 days.During the course of the study,the subjects developed a subcutaneous injection of morphine injection and the oral dose of the sustained-release opioid was adjusted in accordance with the pain intensity of the patient.At the time of the scheduled observation,the number of burst pain,NRS pain score,abdominal distension score,UB A pain behavior score,the number of burst pain,morphine dosage of 24 hours,KPS score,and satisfaction with acupoint treatment of competent physician and the patient.Results:In this study,50 subjects were included,no subjects were excluded from the study protocol.According to the principle of intention-to-treat analysis of the results of randomized controlled trials,the final results of this study were based on the statistical analysis of full analysis set(50 cases).1.Clinical efficiency:?Abdominal pain relief rate:seven days after the treatment group pain relief rate was 86.0%,placebo group pain relief rate was 52.0%,The abdominal pain relief rate of the true-drug group was higher than the placebo group(P= 0.015).After three days of the end of treatment,the number of pain relief in the two groups was still different(P=0.004).For the patient in the two groups without oral morphine,only use of acupoint application to treat abdominal pain,true-drug group abdominal pain relief rate was 88.8%,the control group abdominal pain relief rate 40%,and the rate of abdominal pain relief was still higher in the trial group than in the control group 3 days after the end of treatment.?Abdominal bloating remission rate:After seven days of treatment,the treatment group abdominal distension was 80.0%,and the rate of abdominal distension was 44.0%percent in the placebo group.The Abdominal bloating remission rate of the true-drug group was higher than the placebo group(P=0.009).At the end of treatment 3 days,the number of bloating remission in the two groups was still different(P=0.009).For the patient in the two groups without oral morphine,only use of acupoint application to treat abdominal pain,the rate of abdominal pain was 88.9%in the true-drug group and 53.5%in the control group.The remission abdominal distension rate was still higher than that of the control group after 3 days of treatment.2.UBA pain behavior score:After 7 days of treatment,the experimental group pain behavior score(1.95±1.22)points,While the placebo group was(2.90±1.62)points,the two groups were statistically significant(P=0.044).3.24 hours of bursts pain:Two groups' 24 hours of burst pain on the 1st,4th,7th,10th day were no significant difference.4.Total morphine of 24 hours:The two groups total morphine of 24 hours on the 1st,4th,7th and 10th day were no statistically significant difference.5.KPS score:The two groups' KPS score on the 7th and 10th day were no significant difference.6,Satisfaction and satisfaction rate:After 7 days of treatment,there was no significant difference in the satisfaction of the two groups of subjects' physician for acupoint application treatment.The satisfaction rate of the physician in the placebo group was 96%for acupoint application treatment,and the satisfaction rate was 92%for the physician in the test the treatment group.There was no significant difference in the satisfaction of the two groups of subjects for acupoint application.The satisfaction rate of the subjects in the placebo group was 92%,and the satisfaction rate of the subjects in treatment group was 88%.7.Safety assessment:The skin allergic reactions incidence of 'prescription of ding xiang zhi tong ' acupoint application to treat cancerous abdominal pain was 4.2%,there was no statistically significant difference(P=1.000)compared with placebo.Compared with the placebo group,'prescription of ding xiang zhi tong ' acupoint application to treat cancerous abdominal pain do not increase the patient's blood routine,urine routine,stool test plus occult blood test,liver function,renal function,electrolyte and ECG test results of the risk of deterioration.Analysis conclusion:1.Mild and moderate abdominal pain of cancer patients with oral opioid analgesic on the basis of the addition of 'prescription of ding xiang zhi tong' acupoint application treat,can further reduce the symptoms of abdominal pain,reduce the effective rate of abdominal distention was 86.0%,reduce abdominal pain is 80.0%.2.Mild abdominal pain of cancer patients simple use 'prescription of ding xiang zhi tong'acupoint application treat can effectively relieve symptoms of abdominal distention 'and pain.It is suggested that it can replace the three ladder analgesic drugs in the treatment of mild cancerous abdominal pain.3.The 'prescription of ding xiang zhi tong' acupoint application to treat abdominal distention and pain can reduce the UBA pain behavior score of cancer patients,but it can't reduce the dose of morphine.4.The 'prescription of ding xiang zhi tong' acupoint application to treat abdominal distention and pain is higher acceptance by clinicians and patients.5.The 'prescription of ding xiang zhi tong' acupoint application to treat abdominal distention and pain may lead to local skin allergic reactions,but no systemic toxicity,clinical use is safety and effective. |
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