Analysis Of The Factors Of Immunization And Infection In Repeated Cases Of Spontaneous Abortion

Objective: The relevant laboratory and detection was done to further explore the influencing factors about the immune and infection factors of recurrent spontaneous abortion patients.Methods:1.We selected 300 cases of recurrent spontaneous abortion patients as the experimental group in our hospital from May 2013 to May 2015, and we also selected 115 healthy women who came to our hospital for a medical examination as the control group over the same period.2. We used enzyme-linked immunosorbent assay to detect subjects' serum of the two groups in order to test the levels of anti-cardiolipin antibody, anti-endometrial antibody, and anti-sperm antibody.3. We detected the levels of Chlamydia pneumoniae antibody and anti-nuclear antibody in the subjects' serum of the two groups through indirect immunoassay and gold spot immune-chromatography.4. We detected six sex hormones of the levels of the two groups by chemiluminescence method.Results: Patients of the experimental group whose antibodies were positive were 162 accounting for 54%. There were 98 cases in the experimental group whose anti-cardiolipin antibodies were positive, and 36 cases were positive for anti-nuclear antibodies, then 47 cases were positive for anti-endometrial antibodies, also anti-sperm antibodies positive were 21 cases; Healthy women of the control group whose anticardiolipin antibodies were positive were 11 cases, while anti-nuclear antibodies positive are 4 cases, and anti-endometrial antibodies positive were 3 cases, then anti-sperm antibodies positive were 3 cases.The difference between the two groups was significant(P < 0.05). 55 patients in the experimental group existed of virus and mycoplasma infection accounting for 18.3%. Patients who infected with mycoplasma urealytium in the experimental group were 13 cases, while Chlamydia trachomatis positive were 10 cases, both positive were 4 cases. 54 patients of the experimental group were detected with TORCH infection, and Toxoplasma gondii Ig M were present in 37 cases' serum. The control group whose ureaplasma urealyticum were positive was 1 case, Chlamydia trachomatis positive were 2 cases. Infected with ureaplasma urealyticum and chlamydia trachomatis was 1 case andTORCH Ig M1 positive was 1 case. TORCH infection in experimental group was significantly higher than that of the control group. The difference between the two groups was significant( P < 0.05). There were 217 cases in the experimental group, accounting for 72.3%, whose six steroid sex hormones were abnormal. While in the control group whose six steroid sex hormones were abnormal were 8 cases accounting for 7%. The rusults about six steroid sex hormones of the experimental group were significant higher than those of the control group( P < 0.05). There were 18 cases whose chromosome were abnormal in the experimental group accounting for 6%, while 2 cases of the control group whose chromosomes were abnormal accounting for 0.9%. The results of chromosome abnormalities in the experimental group were significant higher than those of the control group( P < 0.05). There were 7 cases with uterine malformation accounting for 2.3%, while there was none in the control group.Conclusion: Immune and infection factors in addition to the endocrine factors are the common causes of recurrent spontaneous abortion incidence. Further deep reasons for the prevention of recurrent need to be found out to prevent recurrent spontaneous abortion, and we believe those have important significance.