| Background:Children bronchial asthma is the most chronic diseases of respiratory system. With the promotion of social industrialization, the increase of allergens, chemical stimulation, tobacco haze and pathogenic bacteria, the incidence and mortality of the disease are increasing in the world, which is a serious threat to the health of children, in the recent years. The prevention and treatment of bronchial asthma has attracted the attention of the whole world. The World Health Organization has involved it into the global control strategy. Nowadays, western medicine in the treatment of asthma mainly uses adrenal sugar cortical hormone, M receptor blockers, leukotriene receptor antagonists, beta 2 adrenergic receptor excited agent, antihistamines, theophylline, immune inhibitors and so on. Although asthma has been controlled, emergence of many side effects also occurs, and some patients cannot tolerate with it. Thus, the use of traditional Chinese medicine treatment for prevention of bronchial asthma in children has certain advantages. Through Sun Hao’s academic thoughts of old Chinese medicine, and his experience of the treatment and prevention of bronchial asthma in children from its emphasis on the prevention and treatment of children’s bronchial asthma, this paper aims at improving the clinical efficacy of bronchial asthma in children.There is a long history of traditional Chinese medicine on prevention and treatment of children with bronchial asthma, formed its own characteristics, and achieved good results. Sun Hao engaged in pediatric clinical teachers, teaching more than 60 years, under the tutelage of his father--the famous doctor Sun Jinchen in Yi Zheng. Sun Hao is the fifth generation; he is the country’s fifth batch of the old Chinese medicine experts and academic experience in succession guidance. He has profound theoretical background and rich clinical experience, and has a unique point of view into the bronchial asthma in children. He believes that in asthma remission stage, the overall regulation of active defense in children can greatly improve the long-term clinical effect. Sun Hao believes:children with bronchial asthma attack is as a result of both inside and outside interaction; phlegm is the internal cause and external pathogenic factors include diet, fatigue feeling, external activation of latent phlegm. In the attack period, the symptoms are mainly outside; the treatment method is mainly to quell the asthma, and reduce the cough. In the remission stage, the symptoms are mainly for lung, spleen, and kidney deficiency, especially the spleen and kidney deficiency in the latter stage; the treatment method is mainly to supplement. When the ancient physicians discussed about bronchial asthma pathogenesis, the pathogenic factor of "phlegm" is always inseparable from, "Phlegm" may be the cause of the disease, and may be the product of the product, phlegm production, although associated with many internal organs, sickly, but Mr. Sun believes that it lies in the deficiency of kidney and spleen, spleen kidney yang deficiency leads to retention of phlegm and fluid, which is the key to the remission stage, while most children with asthma have allergic constitution. Clinical common shortness shows as shortness of breath, fatigue, pale white complexion, chills, cold extremities, urine clear long, stool pond, pale tongue with white fur, weak pulse weak or heavy fine etc. deficiency symptoms, is mainly caused by congenital Original Yang loss or chronic damage of Yang. Remission period is always the key pathogenesis. The ancients said:"The phlegm generates from the kidney, comes from the spleen, and is stored in the lung". Kidney is the root of the energy, the respiratory function of the lung needs the function of the kidney to assist, the kidney deficiency cannot keep the depth of the lung. The respiratory function of the lung needs the assistance of the kidney; Kidney deficiency cannot maintain the depth of the lung, which is the inverse of the air to breathe. In addition, the kidney is in charge of body fluid. The kidney yang deficiency will easily leads to deficiency of Yang, and phlegm is easy to form. Although the "spleen is the source of phlegm, spleen kidney yang", but energy loses will still lead to inability to transport, so as to cause phlegm. The yang kidney is the basic for the strong spleen, and the health of the spleen is the fundamental of energy. Therefore, Doctor Sun proposed the idea of " emergency treatment for lung, non-emergency treatment for spleen and kidney ", During the remission for children with asthma, treat the kidney, strengthen the spleen, aiming at the root of sputum, so that the foundation is full, then the phlegm is gone by itself.Target:This thesis is under the careful guidance of Professor Sun Hao. This paper systematically studies and summarizes the professor in treating pediatric bronchial asthma in remission stage experience, and academic thought, discusses the therapeutic effect and mechanism of the treatment of children with bronchial asthma in the remission stage of children with bronchial asthma. This paper put forward the deficiency of spleen and kidney yang, retention of phlegm and fluid is the key pathogenesis, warming kidney and invigorating spleen are the main treatment method. Warming and invigorating kidney yang, strengthening innate, warming and resolving phlegm wet, improving the physical deficiency, these will lead to the phlegm no longer exists, and the lungs are clean. Clinical research in this paper compares drugs for warming kidney and invigorating spleen, with pure glucocorticoid inhalation therapy. By comparing the main symptoms and minor symptoms of the two groups, respiratory peak flow velocity (PEF) before and after treatment, and C-ACT score in the 3 months before and after treatment, this paper evaluates the clinical efficacy and safety of the treatment of children with bronchial asthma in children with bronchial asthma by Sun Hao, combines theory and clinical research to explore the effect of warming kidney and strengthening the spleen to treat the children with asthma, and provides an effective method for the treatment of children with bronchial asthma in remission stage.Methods:Selects 60 cases of bronchial asthma in children during remission stage, which Chinese medicine considers as the spleen and kidney yang deficiency; 1:1 divided into treatment group and control group,30 cases in each group. The two groups of children have comparability in gender, age and other aspects, with no significant difference (P> 0.05). Treatment group:to give warm kidney and spleen decoction,1 dose/day,2 times/day,100 ml concentrated decoction. Control group:glucocorticoid inhalation of Pulmicort Turbuhaler, equivalent to budesonide dose was 0.1 mg per day,1 times per night. Both the two groups were treated for 3 months, followed up for 3 months. During the medication, if bronchial asthma becomes serious, then the routine treatment of acute exacerbation of bronchial asthma will be executed. After the treatment, the changes of main symptoms and signs of all patients were observed and recorded, and the changes of respiratory peak flow velocity (PEF) and C-ACT score were observed before and after 4 months,8 months and 12 months treatment.Results:(1) total effective rate:the treatment group was superior to the control group (P< 0.05); the effective rate of the treatment group was 50%, better than that of the control group (P < 0.05), but the total effective rate of the treatment group was 96.67%, compared with the control group (P> 0.05); The efficacy of TCM in treatment group was 63.3%, better than that of the control group (P< 0.05), but the total effective rate was 96.67%in treatment group and 83.33% in control group (P> 0.05). (2) PFE values:the two groups had a significant improvement in PEF values (P<0.05) after 4 months,8 months and 12 months, but the difference was not statistically significant (P>0.05) in the two groups after treatment. (3) C-ACT score:the difference between the two groups were not statistically significant (P> 0.05) after treatment and follow-up first months, the difference between the two groups was statistically significant (< 0.05), and the difference was statistically significant (P< second), in particular, the difference between the two groups was statistically significant (P< 0.01) after third months of follow-up.Conclusion:through the clinical research, Professor Sun Hao’s warming kidney and spleen method has good preventive and therapeutic effect on children bronchial asthma remission stage. It is superior to the western medicine in improving the symptoms and signs of asthma, and to reduce the long-term attack of asthma, which is better than the western medicine control group, so as to prove the rationality of the application of warming kidney and spleen in the treatment of bronchial asthma. This method reflects the advantages of traditional Chinese medicine in the prevention and treatment of asthma in children, the treatment is convenient, the price is low, the effect is reliable, the side effect is little, so it is worthy of promotion. |
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