Clinical Study Of Anticancer Analgesic Cream In The Treatment Of Localized Cancer Pain

Objective: To study the therapeutic effect of anticancer analgesic ointment on cancer pain patients of the ability of living and quality of life by our hospital homemade anticancer and analgesic ointment adjunctive therapy to severe cancer pain(referred to as "pain") clinical observationMethods:According to completely randomized method, the 60 cases of hospitalized patients according to the visiting sequence for 1 to 60, were randomly divided into 2 groups, 30 cases in each group, the experimental group and the control group. Two groups of patients before treatment of general information, the degree of pain, pain score(NRS score), the onset time of analgesia, pain, quality of life(KPS score) were not statistically significant, they were comparable.Test group was treated by oral administration of tramadol hydrochloride sustained release tablets and external application of anticancer analgesic ointment in the treatment, the control group oral hydrochloride tramadol sustained-release tablets and topical placebo in the treatment, the patients in the two groups before and after treatment were pain, analgesic onset time, pain, quality of life and the safety of the recording and comparisonResults:(1)Pain distribution: after treatment between the two groups has statistical significance(P < 0.05), the treatment after painless + mild pain patients in test group were 46.6%, control group(20.0), moderate + severe pain patients in test group were 53.4%, 80.0% in the control group.(2) NRS score: two groups after treatment showed no significant difference(P < 0.05); the experimental group before and after treatment was statistically significant difference(P<0.05), the control group with no significant difference(P>0.05).(3) Pain score: the two groups had no statistically significant difference(P>0.05); the experimental group before and after treatment was statistically significant difference(P<0.05), the control group had no significant difference(P>0.05).(4) The onset time of analgesia: the two groups had no statistically significant difference(P>0.05); the experimental group before and after treatment was statistically significant difference(P<0.05), the control group had no significant difference(P>0.05).(5) KPS score: the difference between the two groups had no statistical significance(P>0.05); the test group was statistically significant difference(P<0.05), the control group had no significant difference(P>0.05).( 6)Pain relief: there was significant difference between two groups(P<0.05); 30 cases of test group patients pain reliefwas 56.7%, with 30 patients in the control group degree of pain relief was 33.3%.(7)In the course of the study, two groups of patients did not appear on the important organs induced by drugs in heart, liver and kidney damage and other adverse events.Conclusion:Tramadol hydrochloride sustained release tablets combined with anticancer analgesic ointment in the treatment to severe cancer pain role was superior to hydrochloride tramadol sustained-release tablets combined with placebo and to relieve pain, shorten the pain onset time, improve the quality of life and can effectively enhance the analgesic effect and safety of good, worthy of further clinical promotion and research.