| [Research Background]Lung cancer is the leading cause of death in patients with malignant tumors.Globally,1.8 million new lung cancer patients each year,accounting for 13%of cancer incidence,and about 1.6 million patients die of lung cancer every year.It is the highest cancer death rate among males and developed countries in the world..At present,surgery is still the treatment of choice for early stage lung cancer.For most patients,the choice of complete tumor resection has a good long-term survival rate,but there are different degrees of postoperative pain after surgery.Such a development after surgery,for at least 2 months,need to rule out other causes,especially the pain caused by a certain cause before surgery is defined as chronic post-surgical pain syndrome(CPSP).In clinical practice,the incidence of CPSP in adults is 11.5%to 47.0%,and the incidence of CPSP in thoracotomy can be as high as 30%to 50%,13%of which is moderate to severe pain,which seriously affects the quality of life of patients..At present,the traditional clinical treatment of Western medicine for chronic pain after lung cancer has a single method,obvious side effects,and the clinical effect is not significant.The clinical effect of traditional Chinese medicine oral medication for postoperative chronic pain is not satisfactory;according to the clinical experience of the instructor,it is found that the pathogenesis of chronic pain after lung cancer is mainly qi and blood stasis,venous stagnation,no pain;"For the best policy,as appropriate,with other methods;plum blossom needle stab therapy is to stimulate a certain part of the body to adjust the body's function,to treat the disease,with the effect of promoting blood circulation,relieving collaterals and relieving pain,directly to the disease,can be directly paralyzed,Make the veins smooth,the so-called "blood gas and general meridians pass through."Therefore,we set up this topic to further explore the efficacy of plum blossom acupuncture in the treatment of chronic pain after lung cancer surgery,and confirm the efficacy of this method in the treatment of chronic pain and clinical symptoms,evaluate its safety,and explore the combination of traditional Chinese medicine and external medicine.The new treatment mode for treating chronic pain after lung cancer provides a scientific basis for the treatment of chronic pain in lung cancer after the treatment of plum blossom acupuncture.[Objective]The main purpose of this study is to treat chronic pain after lung cancer surgery with the traditional Chinese medicine treatment of plum blossom acupuncture combined with tramadol hydrochloride sustained-release tablets under the guidance of traditional Chinese medicine theory of "Promote blood circulation,relieve collaterals and relieve pain".Compared with the treatment of Mado sustained-release tablets,the KPS score,NRS score,BPI score.TCM symptom score,blood routine,blood coagulation,liver and kidney function,tumor mark,tramadol hydrochloride were compared by comparing the two treatments.The total dosage of sustained-release tablets confirmed the effectiveness and safety of plum-needle acupuncture in the treatment of chronic pain after lung cancer treatment,providing further objective basis for formulating clinical treatment strategies,filling the gaps in relevant clinical experience,and exploring the joint treatment of Chinese medicine.A new mode of drug treatment for chronic pain after lung cancer surgery.[Research Methods]This study used a prospective randomized controlled trial to compare 60 patients who met the inclusion criteria between February 2018 and February 2019,and were randomly assigned to a group of 30 patients with acupuncture plus acupuncture plus oral tramadol sustained-release tablets and oral administration.3 0 cases of single-drug tramadol hydrochloride sustained-release tablets control group.The experimental group was treated with plum blossom acupuncture combined with tramadol hydrochloride sustained-release tablets,and the control group was given tramadol hydrochloride sustained-release tablets.The patients were observed and recorded before treatment,on the 7th day,the 14th day,and after the treatment.Score,NRS score,BPI score,TCM symptom score and total amount of tramadol hydrochloride sustained-release tablets;before and after treatment,blood routine,hemagglutination,liver and kidney function,tumor markers were detected and recorded;The data of each group's points and counts were calculated and analyzed by SPSS 21.0 statistical analysis software.The observation,statistics and summary of the efficacy are finally carried out.[Research Results]1.General information:Statistical analysis was performed on the age,gender,pathological type and surgical procedure of 60 patients enrolled,P>0.05,no statistical difference,and clinical observation was possible.2.NRS in patients with chronic pain after lung cancer:2.1 According to the degree of pain relief in patients,the remission rate was 85.71%in the experimental group and 60.71%in the control group.The two groups were tested by the chi-square test(P=0.035,P<0.05),the difference was statistically significant.2.2 The NRS scores of the two groups were statistically analyzed.The results showed that the NRS scores in the experimental group and the control group were lower than those before the treatment,and there was a statistical difference(P<0.05),indicating that the single treatment or the combination treatment NRS can be reduced;the NRS scores of the experimental group were lower than those of the control group,and the difference was statistically significant(P<0.05).The KPS scores of the two groups were statistically analyzed.The results showed that the KPS scores in the experimental group were significantly higher than those before treatment(P<0.01).The KPS scores after treatment were significantly higher than those before treatment(P<0.05).Compared with the control group,the KPS scores of the experimental group were higher than those of the control group,and there was significant statistical difference(P<0.01).4.Quantitative TCM symptom scores Statistical analysis of the TCM symptom scores of the two groups of patients showed that the test group had significant improvement in cough,chest pain,chest tightness,fatigue,upset,insomnia,tongue coating and pulse.Relief,and the difference was statistically significant;in the control group,chest pain,upset and insomnia were significantly improved before and after the symptoms were relieved;and the difference was statistically significant.5.BPI scores The BPI scores of the two groups were statistically analyzed.The results showed that the daily activities,emotions,walking ability,normal work,relationship with others,sleep and life enjoyment scores in the experimental group were lower than those before treatment.There was a statistical difference(P<0.05).In the control group,the scores after mood and sleep treatment were lower than those before treatment(P<0.05).The experimental group and the control group were compared,and the scores in daily activities,normal work,relationship with others,and sleep were lower than those in the control group,and there was statistical difference(P<0.05).6.Blood routine,blood coagulation,tumor,liver and kidney function for the two groups of patients with serum osteocollin(Cyfra21-1),neuron specific enolase(NSE),carcinoembryonic antigen(CEA),squamous epithelial cells Statistical analysis of anti-cancer related antigen(SCC)showed that there was no significant change in Cyfra21-1,NSE,CEA and SCC levels before and after treatment in the experimental group and the control group(P>0.05).,suggesting that the treatment method of this subject has no statistical difference to the above laboratory indicators.There were no obvious discomforts in the treatment of the two groups.The laboratory indicators such as vital signs(body temperature,respiration,pulse,blood pressure),blood routine,blood coagulation,liver and kidney function were not abnormal.[Conclusions]1.For the treatment of chronic pain after lung cancer surgery,combined with single-agent tramadol sustained-release tablets,combined with traditional Chinese medicine plum blossom needle acupuncture treatment can improve the pain intensity of patients and improve the pain relief rate.2.Compared with the single-drug tramadol sustained-release tablets,combined with traditional Chinese medicine plum blossom needle acupuncture treatment can improve the overall quality of life of patients.Compared with the single-drug tramadol sustained-release tablets,combined with traditional Chinese medicine plum blossom needle acupuncture treatment can improve some TCM syndromes of patients with chronic pain after qi stagnation and blood stasis type lung cancer.4.Compared with single-agent tramadol hydrochloride sustained-release tablets,combined with traditional Chinese medicine plum blossom needle acupuncture treatment can improve the impact of pain on patients' lives.5.Plum blossom acupuncture combined with tramadol hydrochloride sustained-release tablets have no effect on the patient's swelling,liver and kidney function,blood routine,blood coagulation and other indicators,and the safety is good. |
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