| Aim:60cases of hip, knee arthroplasty patients were divided into treatment group and observation group, the treatment group were treated with traditional Chinese medicine of supplementing qi and activating blood circulation method intervention. Through the comparison of treatment group and observation group, Evaluation of traditional Chinese medicine on the hip, knee arthroplasty in patients with deep venous thrombosis incidence and coagulation indexes, Main outcome measures for the four items of blood coagulation, plasma protein S and protein C.Method:The task collect the data of2010February to2012February in China Academy of Chinese Medical Sciences Wangjing Hospital,who met the inclusion criteria for the hip, knee arthroplasty patients, through the comparison of before and after operation in four coagulation, plasma levels of protein S and protein C. Investigating60cases of hip, knee arthroplasty patients,60cases of hip, knee replacement were randomly divided into the treatment group and observation group, the treatment group were given preoperative Decoction, agent1/day,2times/day, sooner or later served, for5days; The patients in the observation group5days before and24hours postoperatively not medicine and anticoagulant drugs intervention.In the morning and in the first postoperative day blood tests for coagulation four, protein S, protein C levels. In operation before and after coagulation indexes as parameters, are paired t test.Result:1.The selected group of60patients with coagulation tests show, before treatment two groups at baseline alignment, with comparable.2. Comparison of the incidence of deep venous thrombosis:The treatment group of30cases, a case of calf muscular venous thrombosis happen, the incidence rate of3.3%; The observation group30cases,3case of calf muscular venous thrombosis happen, the incidence rate of10%, That group therapy in the prevention of deep vein thrombosis with clinical significance.3. Coagulation four comparison:The treatment group before and after operation in four coagulation values were decreased than the observation group, the treatment group of prothrombin time before operation is13.47±1.571s,after operation isl2.52±0.627s; Fibrinogen before operation is3.50±0.86g/L,after operation is3.43±1.48g/L, compared with before treatment was reduced obviously(P<0.05), and maintain stability; The observation group of prothrombin time before operation is14.03±1.523s,after operation is14.52±0.641s; Fibrinogen before operation is3.52±0.73g/L,after operation is3.72±0.52g/L. The treatment group in the prothrombin time, fibrinogen in the observation group than the low average value, it proves Chinese medicine having a positive effect on PT, Fib.4. Coagulation plasma levels of protein S and plasma protein C:The treatment group before and after the operation of plasma levels of protein S and plasma protein C were observed in group increased, the treatment group of plasma protein C (PC) before the operation is3.5±1.10ug/ml, after operation is3.8±1.32ug/ml, plasma protein S (PS) before the operation is8±2.61ug/ml, after operation is9.6±4.10ug/ml, were elevated before operation (P<0.05), and maintain steady; The observation group, plasma protein C (PC) before the operation is3.3±1.07ug/ml, after operation is3.1±1.42ug/ml, plasma protein S (PS) before the operation is7.6±1.07ug/ml, after operation is8.1±1.42ug/ml, group therapy plasma protein C (PC), plasma protein S (PS) on average compared with the observation group increased, the description of PC and PS have stimulative effect.Conclusion:Supplementing qi and activating blood circulation on the hip, knee arthroplasty inpatients with coagulation index to have certain positive effect, can reduce the postoperative blood high coagulation state, promote the plasma levels of protein C and protein S plasma generation.Description method of Supplementing Qi and Activating Blood Prescription relevant to clinical reality, in the prevention of deep vein thrombosis have further significance of research and promotion. |
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