A Functional Magnetic Resonance Study Of The Immediate Effect Of Acupuncture On Yanglingquan On Passive Exercise In Patients With Hemiplegia Due To Cerebral Infarction

Limb movement disorde is a common sequela of stroke,also it is the biggest obstacle preventing patients from returning to the society,and it strongly affects the patients’quality of life.In clinical practice,acupuncture is a commonly used therapy of movement disorders after stroke,but its mechanism is not clearly explained currently.It is therefore necessary to further study acupuncture’s mechanism of improving movement disorders after stroke.In recent years,functional magnetic resonance imaging(fMRI) provides a non-invasive, visualize,high spatial resolution research tool for the study of the mechanism of acupuncture.In this study,we adopt functional magnetic resonance imaging to explore the central nervous system’s immediate effects of acupuncturing Yanglingquan(GB34)on the stroke patients who were executed passive movement.Purpose:To observe six cases’brain activation of left hemiplegia after cerebral infarction,who were acupunctured Yanglingquan,sham point before and after the left hand movement,and then to investigate the immediate impact of acupuncture to the cerebral cortex.Methods:Firstly,the passive movement of thumb and index finger was executed,and then acupuncture the Yanglingquan or sham point,finally repeat passive finger moving.The whole operations were carried out when the patients were scaned.This study adopted the block design pattern.Using generalized linear models,repeated measures analysis of variance methods for data analysis.Results:The areas of left Insula,right Precentral Gyrus,right Postcentral Gyrus,right Inferior Frontal Gyrus,right Middle Frontal Gyrus, right Superior Parietal Lobule.right Middle Temporal Gyrus,right Angular Gyrus,right Precuneus, Bilateral Inferior Parietal Lobule,Bilateral Superior Temporal Gyrus,Bilateral Supramarginal Gyrus were found apparent activation after the Yanglingquan was acupunctured.And the positive activation were found in the areas of the left Declive, left Inferior Occipital Gyrus, left Culmen and left Tuber,Bilateral Fusiform Gyrus,Bilateral Lingual Gyrus,Bilateral Cuneus.negative activations were found in the areas of Meningeal,Sulcus,Subependymal veins.The right Precentral Gyrus and Postcentral Gyrus were activated after the passive movement of left fingers.The left Cingulate Gyrus,right Posterior Lobe,Anterior Lobe and Cerebellar Tonsil consist the brain’s positive areas when acupuncture Yanglingquan compared with sham point.Right Precentral Gyrus and Middle Frontal Gyrus were found positive when sham point was compared with Yanglingquan.During interact effect,the positive areas were found at left Posterior Lobe,Anterior Lobe,Cerebellar Tonsil,Culmen,Parahippocampal Gyrus,Inferior Frontal Gyrus,Insula,Precentral Gyrus.Conclusion:It is a complex brain network adjustment process for acupuncture Yanglingquan aimed at improving the motor function of patients with hemiplegia.It involves the combination of immediate effects and delayed effects,and also the combination of separation and integration of brain function.The activation of brain function areas resulting from passive finger movement provided fMRI evidence of rehabilitation for patients with hemiplegia.The Cerebellar,Parahippocampal Gyrus,Insula and related motor areas were proved very important in the acupuncture treatment of hemiplegia after stroke through interact effect analysis.