Gb 34 Point Acupuncture For Stroke Patients With Hemiplegia Passive Movement Based On The Granger Causality Of Fmri Study

Stroke is still one of most frequently-occurring diseases currently in our country, of which70%to80%of stroke patients can not live independently due todisability, evidence-based medicine confirmed that rehab il i tat ion is the most effective way to reduce its morbidity, traditional acupuncture treatment has been playing an important role in the recovery of the neurological deficit after stroke. Acupuncture treatment has been in the guidance of the traditional meridian theory, diagnosis and treatment carried out under the guidance of principle, has a wealth of research in the treatment of stroke for thousands of years, in recent years, functional magnetic resonance has been employed in many research to explain the mechanism of how acupuncture promote recovery of stroke from the point of view of the medical imaging.But currently, the researches of acupuncture to promote recovery of brain function are mainly to undirected network connection, in this study we comparing the healthy group with the apoplectic hemiplegia group, using Granger causality analysis to explore the impact of acupuncture Yanglingquan(GB34) on stroke patients with brain function, which can be speculated that the information the causal flows to the variables.Objective:1. Explore the Granger causal effect when passive finger movement before and after acupuncture and the mechanism of how acupuncture can promote patients recovery;2. The difference of Granger causality effect before and after acupuncture GB34and sham point when the passive finger movement.Methods:According to the diagnostic and inclusion criteria, In6cases of left hemiplegia after cerebral infarction patients and6cases of healthy volunteers, a total of12cases of subjects. Test for each subject in acupuncture GB34/sham point before and after each one on the left thumb and forefinger passive movement, each subject underwent two tests of true point and fake point, simultaneous acquisition the subjects’ block mode brain functional magnetic resonance images (fMRI).Results:1. Hemiplegia group before and after acupuncture passive movement ROI affect brain areas mainly include:left Lingual gyms, right Cingulate Gyrus, bi la teral Cuneus, Precuneus, Cingulate Gyms, effect on ROT brain areas include: bilateral cerebellum, Posterior Cingulate, right Parahi ppocampal Gyms, Thalamus; hemiplegia group interaction effect ROI affect brain areas mainly include:right Inferior Frontal Gyms, Middle Frontal Gyms, Superior Frontal Gyrus, effect on ROI’ brain areas include:left Precentral Cyrus, Postcentral Gyrus, Superior Temporal Gyrus, Middle Temporal Gyrus, Inferior Temporal Gyrus, Insula, Lentiform Nucleus, Claustrum, Fusiform Gyrus, Inferior Parietal Lobule.2. health group before and after acupuncture passive movement ROI affect brain areas mainly include:left Middle Temporal Gyrus, Middle Occipital Gyrus, Cuneus, Anterior Cingulate, Caudate, Cerebellum, right Precentral Gyrus, Precentral Gyrus, Inferior Parietal Lobule, Superior Parietal Lobule, effect on RGI’ brain areas include:left Precentral Gyrus, right Precentral Gyrus,Postcentral Gyrus, Superior Frontal Gyrus, Medial Frontal Gyrus, bilateral Anterior Cingulate; health group interaction effect ROI affect brain areas include:bilateral Cerebellum, Posterior Cingulate, Fusiform Gyrus, Lingual Gyrus, Parahippocampal Gyrus, Precuneus, Cuneus, Middle Occipital Gyrus, Thalamus, left Inferior Temporal Gyrus, Middle Temporal Gyrus, Superior Temporal Gyrus. No area of the brain to influence ROI.Conclusion:The health group has more widely activated brain areas affected by the ROI in the pass ive finger movement, Especial ly between with sports-related brain areas exists bidirectional activation, but the Granger Causality network between the hemiplegia group ROI and other brain areas are relatively sparse, may be associated with nerve fiber damage after a stroke, and related sports network missing relevant, consistent with limb function in patients with movement disorders and abnormal mode; Hemiplegia group acupuncture GB34interaction exists between the ROI and sports networks, execution network somatosensory network, May be related to acupuncture promoting hemiplegic limb function rehabilitation after stroke; Health group acupuncture GB34effects mainly related with memory, visual, somatosensory, and many other brain areas, considerations may the effect of acupuncture between normal subjects and patients is different, its effect mechanism is also different.