Fmri And Dti Imaging Hemiplegic Limb Movement And Acupuncture Yanglingquan Point In The Remodeling Of Brain Function

Apoplexy is the common and frequently occuring disease with high disease incidence, mortality and mutilation rate.Hemiparalysis,one of the present symptoms of apoplexy,makes the patients no self-care,which brings great burden to family and society.Brain plasticity is the important mechanism for cerebral functional recovery,and it is the hot spot of clinical and basic research on apoplexy.Chinese Medicine treatments on apoplexy has a long history with favorable curative effect,among them,acupuncture and moxibustion therapy is the important way for hemiparalysis rehabilitation,while the influence of acupuncture and moxibustion on cerebral function remodeling.Quick development of functional imageology brings the moment of researching on impairment recovery of epencephalic after stroke and the therapy mechanisms of acupuncture and moxibustion.What's more,it provides potent technique support on cerebral function change under normal and pathologic state and the function point and pathway of brain function remolding full-scale,direct view and without injury.This research compares normal persons and apoplexy hemiparalysis,undergoes cerebral function imageology research on different organism state while doing upper extremity exercise and acupuncture Yanglingquan(GB34).At the same time,the reasearch carries out three-dimensional reconstruction and contrast analysis of transactivation area,fiber and disease focus.1.Cerebral function imaging on hemiplegic patient taking Yanglingquan(GB34) acupuncture and left upper extremity exercise.Objective:Acquiring cerebral transactivation area results of left upper extremity exercise and GB34 acupuncture under pathological state,discussing the relation between hemiparalysis limbs movement and cerebral function activation,also the influence of cerebrum motor function area while acupuncturing GB34.Methods:Assessing 5 patients' nerve function collecting patient structure image and Block model cerebral function imaging with fMRI.Results:Left upper extremity exercise obviously activates bilateral cerebellum,basal ganglia kernel,cerebrum primary sensorimotor cortex(SM1)and posterior parietal cotex(PPC),right parietal cotex is more active than left;acupuncturing GB34 obviously activates mesencephali of brain stem,left premotor cortex(PMC) and PPC.Conclusion:acupuncturing GB34 can regulate tension feedback path of central nervous system (CNS) and affect CNS's motor coordination integration which ameliorate spasticity and motor function;cerebral activation areas of upper extremity exercise are concerned with compensation of CNS,which declares that cerebral function remolding is one of the important mechanism of limbs motor function recovery.2.Cerebral function imaging of acupuncturing GB34 and left upper extremity exercise and their comparative study in normal personsObjective:Acquiring two kinds of normal cerebral activation by cerebral function imaging of acupuncturing GB34 and left upper extremity exercise in normal persons,discussing the neural conduction path of extremity exercise and cerebral effect of acupuncture.Analyzing the difference and significance of motor and acupuncture cerebral activation in normal and physiological states.Methods:Collecting 8 patients' structure image,left extremity motor and Block model of acupuncturing left GB34 cerebral function imaging with fMRI.The data processing is the same with hemiplegia group.Results:motor activation areas in normal group locate at left cerebellum,right cerebral SM1 and part PPC;acupuncturing GB34 activation areas locate at left cerebellum,bilateral posterior central gyrus and inferior parietal lobule;two groups have the same activation cluster at SM1; there is significant difference between two groups's activation areas.Conclusion:The motor activation areas of normal person match the neural dissection localization of one side limb receiving opposite cerebrum and homonymy cerebellum control; acupuncturing GB34 in normal person responses the centers of motor accommodation.;there is probably more central regulaton mechanism in hemiparalysis extremity than normal one;the different activation effects of acupuncturing GB34 in normal and pathological state generate different feedback regulation action.3.Uniting fMRI and DTI(Diffusion Tensor Imaging) to analyze the mechanism and prognosis of cerebral motor function injury and rehabilitationObjective:Analyzing the relation between motor dysfunction and fiber bundle injury; investigating the injury and rehabilitation mechanism of hemiparalysis extremity's motor path.Methods:According to the inclusion criteria of test 1 and 2,DTI scaning 7 patients,image and data analysis by BrainVoyager and SPSS13.0;processing fMRI,DTI and focus of disease three-dimensional reconstruction and image fusion.Results:There is no obvious difference m FA values of uninjured internal capsule of cerebrum between case group and normal group;the normal group FA values is obviously better than case group;the FA values in hemiparalysis patient's impairment encephalic region is much lower than the uninjured side;please refer to the text for the results of fMRI,DTI and focus of disease three-dimensional reconstruction and image fusion.Conclusion:DTI technique can clearly display the compression,breaks and destruction of condition of corticospinal tracts;there is close relationship between locations and sizes of specific impairment and rehabilitation level and mechanism of nerve function.