The Research Of Novel Microfluidic Chips Rapid Preparation Technology

Microfluidics technology has developed rapidly,has brought great changes in medicine,chemistry and life sciences.Microfluidic chip is microfluidics platform,and is currently focus on the micro total analysis system.The purpose of this paper topic is to develope a novel microfluidic processing technology,which is cost-effective,fast,efficient and easy to operate,can carry out basic researches in the general laboratory,and can be applied to actual microfluidic chips production.Including the design and the process of microstructure,surface modification and bond packages,chip verification examples.First,based on the traditional photolithography projection exposure principle analysis,by means of a reduction projection exposure principle,this paper modified a ordinary business projectors to obtain digital projection lithography system(DLPS),and researched its exposure performance and parameters.The system can fabricate microchannel structure as a stable accuracy of 40?m within 3 hours.Secondly,by comparing the current mainstream modification technology and bonding mechanism,we proposed a microwave combinedn purified oxygen to develop low temperature plasma discharge test method,namely using household microwave ovens and vacuum hood and some conventional biochemical laboratory supplies,can be successfully modified and bonding PDMS,its bonding effects can meet the packaging requirements of ordinary lab on a chip and microfluidic chips.At the same time,through observed he changes of surface contact angle after the modified,the chip package for reasonable planning bond alignment and other operations deadlines,provide a reference.Furthermore,through the study of the mechanism of UV ozone modification,this paper designed a PDMS material surface-modified device,by means ozone ultraviolet illumination technology,and using the three factors and three levels orthogonal to design method to study modification effect of irradiation time,distance illumination and Oxygen concentration parameter,and combined with 50 ? water bath environment,to determin the optimum conditions parameters which can achieve PDMS substrate(PDMS or glass)material bonded based on ultraviolet ozone technology.Finally,in order to verify the effectiveness of the microfluidics technology,this paper through researching and analysising the theoretical of a variety of traditional micro-mixer system parameters and flow conditions,designed a passive modular "Pat-shaped" micro mixer chip,effectively reducing the time required to mix and channel length.Overall,this paper developed a micro-fabrication technique which can be carried out quickly in an ordinary laboratory,to prepare an efficient,low-cost microfluidic chip,and to be used as a useful complement to traditional classical microfluidics technology,can provide economic research experiment platform for microfluidic chip applications,to a certain extent,can facilitate the promotion of microfluidics technology and rapid development.