The Study On The Correlation Between Serum Levels Of Thyroid Stimulating Hormone And Metabolic Syndrome In Euthyroid Young Adults

Objective The purpose of this study was to investigate the relationship between serum thyroid stimulating hormone levels(TSH)and metabolic syndrome(MS)with its components in euthyroid young adults,and to explore the correlation between hyperuricemia and MS.Methods Collected 687 euthyroid patients from Ningxia Medical University cardio cerebral vascular disease hospital of physical examination office from September 2016 to September 2017,which including 396 patients with MS,291 males and 105 females,and collected 104 healthy subjects at the same period.Collected the normal information of the subjects at the same time,including gender,age,height,weight,body mass index(BMI),fasting plasma glucose(FPG),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),systolic blood pressure,diastolic blood pressure,serum TSH and uric acid.The high reference value of serum TSH was defined > 2.5u IU/m L according to the large-scale epidemiological survey of the National Academy of Clinical Biochemistry(NACB).Results1.In Ningxia area,the incidence rate of MS was 15.38% in euthyroid young adults,of which 11.30% are males and 4.08% are females.The incidence rate of MS in males is significantly higher than that in females.2.The incidence rate of MS was significantly higher in the high normalgroup of TSH among MS groups.BMI and TG were increased significantly and HDL-C was decreased significantly in the high normal group of TSH,the differences between the two groups were statistical significance(P<0.05),of which FPG,systolic blood pressure,diastolic blood pressure and uric acid had no statistical significance between the two groups.3.The correlation between the level of TSH in the normal range and the components of MS in MS groups:the serum TSH was positively correlated with BMI and TG,and was negatively correlated with HDL-C.4.The incidence rate of overweight or obesity was significantly higher in the high normal group of TSH than the low normal group(61.07% vs 54.95%).5.The incidence rate of hyperuricemia in the high normal group of TSH was significantly higher than that in the low group(44.66% vs 38.82%);Meanwhile,the incidence rate of hyperuricemia in the high normal TSH of MS group was slightly higher than that of MS in the low normal TSH(42.94% vs 40.34%).6.There was no statistical differences in TSH levels between different number risk factor groups of MS.(P>0.05).Conclusions1.People with high normal TSH have increased risk of MS.2.In the euthyroid population,the influence of high-level serum TSH on MS components is mainly about obesity and abnormal lipid metabolism.3.The high normal level of TSH is a risk factor for hyperuricemia,and hyperuricemia should be considered as a risk factor for MS.