The Influence Factors Of Thyroid Nodules Morbidity And Its Correlation With The Components Of Metabolic Syndrome

Objective: To evaluate the risk factors of thyroid nodule morbidity and therelationship of metabolic syndrome(MS)and MS components with thyroid nodule in thepopulation of one institution in Dalian.Methods: We studied1880employees of one institution who participated in themedical examination. Anthropometric parameter，career，fasting plasma glucose(FPG)，blood pressure，blood lipid，blood uric acid，thyroid function tests and thyroidultrasonography have been measured and analysed.Results:1.We reviewed the results of ultrasonography of1817persons working forthe institution. The age range was from20years to87years old, and the average agewas（41.24±15.23）years. We found that the thyroid nodules occurred in772persons ata high incidence (42.5%), with men41.1%and women43.0%. In every age group, themorbidities in women were higher than men, but there was no statistical differencebetween men and women（P>0.05）. There was statistical differences in the morbiditybetween men and women in the age group below30（P<0.05） and no statisticaldifference in other groups（P>0.05）. In each age group of both men and women, theincidence of thyroid nodules increased progressively with age with a significantstatistical significance（P<0.05）. There was no statistical differences in the morbiditybetween contacting ray group and non-contacting radiation group（P>0.05）.2.All the participants were divided into2groups by the level of serum thyroidperoxidase antibody (TPOAb)(≤15U/ml,>15U/ml), the morbidities were39.9%and40.8%respectively, with no significant statistical difference（P>0.05）.3.All the participants were divided into8groups by the level of serum thyrotropichormone (TSH). In the groups with TSH which was less than6.00mIU/L, there were nosignificant differences between multiple comparison（P>0.05）. In the groups with TSH which was more than6.00mIU/L, there were no significant differences betweenmultiple comparison（P>0.05）. The morbidity of the groups with TSH which was morethan6.00mIU/L was higher than the groups with TSH which was less than6.00mIU/Lwith significant statistical difference（P<0.05）.4.By the level of body mass index (BMI), all the participants were divided into4groups. According to BMI group, the incidence of thyroid nodule comparison, the obesegroup of the highest incidence of thyroid nodule, overweight group is the secondsmallest. There were significant differences between multiple comparison（P<0.05）.5.In the groups with fasting plasma glucose (FPG) which was more than3.9mmol/L,the incidence of thyroid nodules increased progressively with the level ofFPG with a significant statistical significance（P<0.05）.The level of FPG in the nodulegroup is significantly higher than that in the control group,the difference wasstatistically(P<0.05).6.The mean value of blood pressure in the nodule group is significantly higher thanthat in the control group, with significant statistical difference (P<0.05).7.The means of total cholesterol,triglyceride, low density lipoprotein cholesterol innodule groups are significantly higher than that in control groups,the difference werestatistically(P<0.05). The mean of high density lipoprotein cholesterol in the nodulegroup is significantly higher than that in the control group,the difference was nostatistically(P>0.05).8.There was no statistical differences in the blood uric acid level between nodulegroup and control group（P>0.05）.9.The prevalence of thyroid nodule was significantly higher in MS group than innon MS group, with significant statistical difference (P<0.05).10.The morbidity of thyroid nodule was significantly higher in fatty liver diseasegroup than in control group, the difference were statistically(P<0.05).11.Using logistic regression to analyse the risk factors of thyroid nodule, the resultsshowed that blood glucose was the risk factor of thyroid nodule after correction for age,gender.Conclusion:1.The thyroid nodules occurred with a high incidence in the populationof the institution, and it was more common in women. In both men and women, theincidence of thyroid nodules increased progressively with age. The morbidity in the agegroup below30was significantly higher in women. There was no statistical differences in the morbidity between contacting ray group and non-contacting radiation group.2.The relationship of thyroid nodule and thyroid function: There was no significantcorrelation between the morbidity of thyroid nodules and the level of serum TPOAb.There was no significant correlation between the morbidity of thyroid nodules and thelevel of serum TSH when the TSH level was less than6.00mIU/L. The morbiditysignificantly increased when the level of serum TSH was more than6.00mIU/L.3.The relationship of metabolic syndrome and MS components with thyroid nodule:The prevalence of thyroid nodule was significantly higher in MS group than in non MSgroup. With higher BMI level, gradually increased the prevalence of thyroid nodules.Inthe groups with fasting plasma glucose (FPG) which was more than3.9mmol/L,theincidence of thyroid nodules increased progressively with the level of FPG.Comparedwith subjects without detected TN，the levels of blood pressure，total cholesterol，triglyceride，low density lipoprotein cholesterol were elevated in subjects with detectedTN.The morbidity of thyroid nodule was significantly higher in fatty liver disease groupthan in control group.There was no statistical differences in the blood uric acid levelbetween nodule group and control group.