The Expressions Of Plasma MicroRna-134 For The Acute Pulmonary Embolism At High Altitude Area

Objective:To observed the plasma expressions of mi RNA-134 in acute pulmonary embolism patients,and discuss the diagnostic value for APE under high altitude area.Methods:Patients with acute pulmonary embolism（APE）,chronic pulmonary embolism（CPE）and healthy volunteers（CG）from high altitude area（3600m）were choosed,20 cases in each group.The peripheral blood plasma were collected,the expressions of plasma miRNA-134 in patient with pulmonary embolism were detected by Taq Man real-time PCR.The diagnostic value of mi RNA-134 for the APE at high altitude were assessed by ROC,and compared with the blood marker D-dimer（D-Di）.Results:（1）The pulmonary arterial systolic pressures（PASP）in the APE group were higher than those of the CPE and CG.The PaO₂ in the arterial blood gas analysis in the APE group were lower than those of the CPE and CG.（2）the levels of plasma mi RNA-134 in the APE group were obviously higher than that of CPE and CG（P<0.05）.（3）The ROC showed that the area under the curve of the plasma miRNA-134 in the APE group was 0.904.At the Cut-off point of 1.62,the sensitivity was 94.7%,while the specificity was 90%.The area under the curve of D-Di in the APE group was 0.889.At the Cut-off point of 9.51ug/ml,the sensitivity was 100%,and the specificity was 80%.Conclusions:（1）The levels of plasma miRNA-134 were significantly increased in APE group at high altitude,which had a higher diagnostic value for APE at high altitude.（2）The specificity of plasma miRNA-134 was better than D-Di in APE groups at high altitude areas,and it still maintains high sensitivity.It could be a new biomarker for APE at high altitude.