Clinical Application Of Photodynamic Therapy Combined With Local Closure For Patients With Moderate To Severe Acne

Objective To evaluate the efficacy and safety of photodynamic therapy(PDT)combined with local closure in the treatment of moderate to severe acne and to prove its clinical utility.Methods A total of 91 patients with moderate to sev ere acne were divided into three groups randomly.31 patients in the combination-therapy group were given 5% ALA-PDT with 3 times for 1 courses.For patients with nodules or cysts larger than 1cm,triamcinolone acetonide combined with gentamycin sulfate an d lidocaine were locally blocked first.30 patients in the ALA-PDT group were only given 5% ALA-PDT with 3 times.30 patients in the drug group take minocycline capsules orally 100 mg a time,twice a day,for 8 weeks.At the 2nd,4th,6th,8th,16 th week,the efficacy and adverse reactions were evaluated.Result(1)At the 6th week,the effective rate of ALA-PDT combined with local closure group was better than other groups,the differences were statistically significant(P< 0.05).At the 16 th week,the effective rate of ALA-PDT combined with local closure group were better than drug group,the differences were statistically significant(P< 0.05),but compared with ALA-PDT group,there was no significant difference(P> 0.05).(2)At the 6th,8th,16 th week,the cure rate of PDT combined with local closure group and ALA-PDT group were better than the drug group,the difference was statistically significant(P< 0.05),in the 16 th weeks,the cure rate of ALA-PDT combined with local closure group was better than other groups,the differences were statistically significant(P< 0.05).(3)The adverse reaction rate in the drug groups was higher than other groups,the differences were statistically significant(P < 0.05).Conclusions(1)Three therapies all achieve good effects in the treatment of moderate to severe acne.(2)Among the three groups,there is a statistically significant difference in the cure rate,the treatment with ALA-PDT combined with local blocking is best,drug therapy was poor.(3)The ALA-PDT combined with local closure therapy has a few adverse reaction and long term cosmetic effect.