The Treatment Of Diabetic Peripheral Neuropathy By Infrared Laser Combined With Drugs

Objective:The effect of infrared laser combined with drugs on diabetic peripheral neuropathy(DPN)was investigated by selecting the best rating scale and serological related indicators.Methods:Step 1:Diabetic patients from the Department of Endocrinology and Metabolism of the Second Hospital of Lanzhou University were enrolled in the study.A total of 57 patients were enrolled in the study,including 32 males and 25 females.All had a history of definitive diagnosis of diabetes,and the application of vibration perception threshold detection in the diagnosis of diabetic peripheral neuropathy in 35 cases,no disease in 22 cases.Then applying NSS,NDS,TCSS and MNIS scale scoring methods for diagnosis and evaluation,and using SPSS17.0statistical software for data processing evaluate the best rating scale.Then the selected patient's data were measured Hcy and CRP by immunoturbidimetry.Pearson correlation analysis and multivariate logistic regression analysis were used to analyze the correlation of serum Hcy?CRP and DPN.Step 2:Patients who have had a history of definitive diagnosis of diabetes were selected,and a sensory threshold of vibration(VPT)test was used to confirm the diagnosis of DPN with the TCSS scale.A total of 67 patients were enrolled,and patients selected randomly divided into experimental group of 35 cases and control group of 32 cases,and assess the current selection of data on peripheral neuropathy.Then it is injected with suitable insulin or oral hypoglycemic drugs to make the blood glucose relatively stable,and the immune nephelometry method is used to determine Hcy and CRP.On the basis of the basic treatment,it is simultaneous administration of methylcobalamin capsules and ?-lipoic acid injection for the treatment of peripheral neuropathy.Mecobalamin continues to be taken during the observation period.Continuous use of?-lipoic acid for 14 days is a course of treatment.Based on the above treatment of peripheral neuropathy,the experimental group was treated with infrared laser.After 2 months,the vibration thresholds,TCSS scores,and serum Hcy and CRP levels were tracked in both groups.SPSS17.0statistical software was used for data processing to compare changes before and after treatment.Result:1.The detection rates of NSS,NDS,TCSS,and MNSI were 74%,69%,83%,and 80%,and the correlations with VPT detection were 0.684,0.653,0.857,and 0.783.The correlations of the four scale scoring methods and VPT were P<O.001,and the difference was statistically significant.2.In terms of specificity,NSS,NDS,TCSS,and MNSI were 86.3%,90.9%,86.3%,and81.8%.In terms of sensitivity,NSS,NDS,TCSS,and MNSI were 74.3%,68.6%,82.3% and80.0%.The ? of NSS,NDS,TCSS,and MNSI were 0.527,0.532,0.635,and 0.614.3.Serum Hcy was correlated with diabetic peripheral neuropathy,and it was positively correlated(r 0.642,P <0.001).Serum CRP was correlated with diabetic peripheral neuropathy,and it was positively correlated(r = 0.753,P <0.001).4.Hcy,CRP,HDL-C,LDL-C were used as independent variables,and diabetic peripheral neuropathy occurred as the dependent variable to perform unconditional logistic regression analysis.Hcy(OR: 1.375 95%CI 1.157~1.863)?CRP(OR: 1.579 95%CI 1.104~2.074)?HDL-C(OR: 0.634 95%CI 0.473~1.127)?LDL-C(OR: 1.249 95%CI 1.076~1.841)were into the equation.Because P<0.05 was considered statistically significant,Hcy(P=0.003),CRP(P=0.001),HDL-C(P=0.027),and LDL-C(P=0.018)were involved in the development of diabetic peripheral neuropathy.The associations were statistically significant(P<0.05).5.The VPT before and after treatment in the red light treatment group was(22.57±4.67)and(1586±3.41)(P=0.032),and it was(21.64±3.73)and(17.39±3.82)(P=0.018)before and after treatment in the control group.It was statistically significant(P<0.05).6.The TCSS scale scores before and after treatment in the red light treatment group were(14.58±2.47)and(8.47±3.51)(P was 0.025),and the control group was(14.27±1.93)and(10.32±3.62)before and after treatment(P was 0.027).they were both statistically significant(P<0.05).7.The serum Hcy before and after treatment in the red light treatment group was(20.36±4.83)umol/L and(15.79±3.21)umol/L(P was 0.038).The control group before and after treatment was(19.48±4.96)umol/L and(17.15 ±3.39 umol/L(P was 0.034).they both were statistically significant(P<0.05).8.The serum CRP levels before and after treatment in the red light treatment group were(8.32±4.88)mg/L and(6.77±3.89)mg/L(P=0.039),and they before and after treatment in the control group were(7.48±3.697)mg/L and(6.21 ± 3.73)mg/L(P = 0.043).they were statistically significant(P < 0.05).Conclusions:1.TCSS scoring method is best for diagnosis and evaluation of DPN.2.Serum Hcy and CRP are associated with the occurrence and development of DPN,and are independent factors in the development of DPN.3.After the treatment of DPN by infrared laser combined with drugs,the efficacy of the treatment is better and the symptom is more obvious relief than the single drug treatment.