| Objective:To study the relation of advanced glycation index (AGI) with the development of impaired glucose regulation, non-alcoholic fatty liver disease (NAFLD), dyslipidaemia, metabolic syndrome (MS), and insulin resistance(IR) that relevant to diabetes mellitus (DM).Methods:1000 subjects over 50 years old were sampled in a public health examination. Demographic data obtained include sex, age, lifestyle, hypertension, dyslipidaemia, family history, waist circumference (WC), blood pressure, body height, body mass index (BMI). Fasting plasma glucose (FPG),2-hour postprandial glucose (2hPG), fasting insulin (FIns), 2-hour postprandial insulin (2hIns), fasting total cholesterol (TC), fasting total triglyceride (TG), blood routine test, blood uric acid, alanine aminotransferase(ALT), glutamicpyruvic transaminase (GGT), blood urea nitrogen (BUN), creatinine (CREA), homeostasis model assessment of insulin resistance index (HOMA-IR) and homeostasis model assessment ofβ-cell function (HOMA-β) were measured. Advanced glycation endproducts (AGEs) were possessed of the characteristic that can emit fluorescence, so we determined the fluorescence intensity of AGEs as an index (AGI) to estimate the contents of AGEs. The sample was divided into NGT, IGT and DM to compare the difference of AGI. The sample was also grouped by AGI (AGI≤50, AGI>50≤100, AGI>100<150, AGI>150≤200, AGI>200) to compare the difference of every biochemical index, and the relation of AGI with MS, NAFLD and MS with NAFLD. Results:The age, BMI, hip circumference (HC), WC, FPG,2hPG, FIns, 2hIns, logAGI, TG, TC, GGT, CREA, SBP, logHOMA-IR, and logHOMA-βof DM group were significantly higher than those of NGT group (P<0.05). The ALT, BUN, DPB, WBC and Plt were not different between DM group and NGT group (P>0.05).The age, HC, WC, FPG,2hPG,2hIns, CREA, SBP, logHOMA-IR, and logHOMA-βof IGT group were significantly higher than those of NGT group (P<0.05).The BMI, FIns, logAGI, TG, TC, GGT, BUN, DPB, WBC, and Plt were net different between IGT group and NGT group (P>0.05).The BMI, HC, WC, FPG,2hPG, FIns, logAGI, GGT, TG, BUN, logHOMA-IR, and logHOMA-βof DM group were significantly higher than those of IGT group (P<0.05).The age,2hlns, CREA, SBP, DPB, TC, ALT, WBC, and Plt were not different between DM group and IGT group (P>0.05).The BMI, WC,2hIns, TG, TC, logHOMA-IR, and logHOMA-βof AGI>50≤100 group were significantly lower than those of other groups (P<0.05). The FPG,2hPG, GGT, CERA, and SBP of AGI>150 group were significantly higher than those of AGI>50≤100 group. The sex, age, FIns, BUN, WBC, and Plt were not different among AGI>50≤100 group and other groups (P>0.05). AGI was positively correlated with FPG,2hPG, FIns, 2hlns, TG, TC, BMI, ALT, GGT, HOMA-IR, HOMA-β, HC, and WC, and it was negatively correlated with age and it was no relationship with BUN and CREA. Multifactorial linear regression analysis found that AGI was independently correlated with 2hINS (t=4.069, P=0.000), TC (t=5.918, P=0.000), WC (t=4.968, P=0.000, TG (t=3.865, P=0.000), and GGT (t=2.497, P=0.013).There was significant difference between NAFLD group and non-NAFLD group of AGI (P=0.000), and it was significant difference between MS group and non-MS group (P=0.000). There was no difference between MS with NAFLD group and MS without NAFLD group (P>0.05).Conclusion:AGI levels are increased in DM, fatty liver and MS. The increase in AGI in these conditions might play an important role in their pathogenesis, especially their accompanying disorders or chronic complications. To use AGI as a surrogate index in predicting the occurrence of chronic complications and design intervention approaches of prevention and therapeutics is a very interesting field of research.
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