The Effect Of Lactation On Bone Metabolism Of Childbearing Age Women

Objective To study the effect of lactation on bone metabolism in childbearing age women by tracing investigation bone metabolic markers and bone mineral density in first single pregnancy women with different duration of breastfeeding.To provide basic research information and reference for the healthy care of the pregnant women and lactating women.Methods Single birth primiparas,aged 25 to 29,with normative pregnancy test in Weihaiwei People 's hospital of Weihai,Shandong Province,from Aug.2015 to Oct.2015,were selected as experimental group,and 30 cases of healthy unpregnant women were set as normal group.All the women's body mass index was 20-25,without diabetes,hyperthyroidism,hypothyroidism,adrenal hyperplasia,liver disease and kidney disease,etc.150 primiparas were divided into 5 groups according to the breastfeeding duration,no nursing group,lactation 6-month group,lactation 12-month group,lactation 18-month group,lactation 24-month group,respectively.Each group has 30 cases.The bone metabolic markers,including Serum Osteocalcin(BGP),? type collagen cross-linking carboxyl terminal peptide(ICTP),serum alkaline phosphatase(ALP),serum calcium(Ca),were detected at 1 weeks,6 months,12 months,18 months and 24 months after delivery,also the calcaneus bone density was detected by ultrasound bone densitometer at the same time.The data was assessed by spss18.0.Results(1)Serum BGP(F=395.98,P<0.01)and serum calcium(F=108.98,p<0.01)in pregnant women were significantly lower than those in non pregnant women at 1 weeks after delivery.Serum BGP levels(t=0.58,P>0.05)returned to normal after delivery in non pregnant women at 6 months.After 6 months of lactation,BGP returned to normal level 12 months after delivery(t=0.71,P>0.05).Other pregnant women returned to normal levels after delivery at 18 months(F=1.41,P>0.05).The no lactation group(t=0.27,P>0.05)and the lactating 6m group(t=1.31,P>0.05)returned to normal at 12 months after delivery;the lactation 12 m group returned to normal after delivery at 18months(t=1.43,P>0.05);the lactation 18 m group(t=3.57,P<0.01)and the 24 m group(t=5.78,P<0.01)were still lower than the normal level after delivery at 24 months.(2)maternal serum ICTP(F=1015.76,P<0.01)and ALP(F=2.74,P<0.05)increased significantly 1 weeks after delivery.Each group of uerpera returned to normal after delivery at 6 months(F=1.59,P>0.05).The levels of serum ALP in the lactating group(t=0.13,P>0.05)and the lactating 6m group(t=0.68,P>0.05)returned to normal level after delivery at 12 months,while those in the other lactating groups recovered to normal levels after delivery at 18 months(F=1.33,P>0.05).(3)The T value of bone mineral density decreased significantly at 1 weeks after delivery(F=8.57,P<0.01).The T value of bone mineral density returned to normal at 12 months after delivery in the non lactating group(t=0.02,P>0.05);The T value of bone mineral density of the lactating 6m group returned to normal at 18 months after delivery(t=0.35,P>0.05);The T value of bone mineral density of the lactating 12 m group returned to normal 24 months after delivery(t=0.42,P>0.05);The T value of bone mineral density in lactating 18 m group and 24 m group was still lower than normal level at 24 months after delivery(F=56.46,P<0.01.Conclusions It can affect the bone and bone metabolism of the parturient women.The longer the breast-feeding time,the longer the time of maternal bone recovery to the prenatal level after cessation of lactation.Bone metabolism index returned to normal earlier than bone density.