| Objective To investigate the risk factors of periventricular-intraventricular hemorrhage in neonatal infants and provide evidence for the prevention and treatment of periventricular-intraventricular hemorrhage;The growth rate of the corpus callosum was monitored by ultrasonography,and the influencing factors of the development of the newborn corpus callosum was analyzed to build a foundation for early evaluation and treatment of neonatal brain development.Part oneAnalysis of risk factors of periventricular-intraventricular hemorrhage in newbornsMethods The study included 515 cases of newborns who were addmitted in our hospital neonatal intensive care unit(NICU)from January 2016 to April 2017,Among them,285 were males(55%),and 230 were females(45%);which including premature children in 283 cases(29-37 w,55%),232 children in term(45%).Brain ultrasound was performed at 1 week after birth.Newborns with periventricular-intraventricular hemorrhage diagnosed,Through neonatal sex,maternal age,gestational age,medication history,pregnancy history,liver disease history,umbilical retraction,intrauterine distress,amniotic fluid,production history,weight,production methods,Apgar score,congenital heart disease,corpus callosum length Logistic univariate and multivariate regression analysis revealed a relationship between prenatal and perinatal factors and periventricular-intraventricular hemorrhage.Result Preterm birth,low birth weight,intrauterine distress,perinatal asphyxia,pregnancy-induced hypertension,maternal liver disease,and anemia are important risk factors for neonatal PIVH.Part twoUltrasound Evaluation of the corpus callosum DevelopmentMethods The study included 97 cases of newborns who were addmitted in Lanzhou University Second Hospital neonatal intensive care unit(NICU)from April 2016 to December 2016,which including premature children in 54 cases(27-34 w),43 children in term.The sagittal length of corpus callosum was measured by ultrasonography per week at 0-6 w of age.Comparing he ratio of length to birth weight(L/M)in preterm and term infants and the growth rate of corpus callosum between 0-6 weeks after birth in preterm infants and term infants by independent sample T test.The relationship between gestational age,neonatal birth weight and corpus callosum growth rate were analyzed.Results(1)The sagittal length of the corpus callosum in neonatal were correlated with gestational age and birth weight(P<0.01);(2)The ratio of the length of the corpus callosum premature children with birth weight(L/M)as compared to full-term children,premature children less than full-term children,statistically significant(P <0.01);(3)The length of corpus callosum at 0 weeks,2 weeks,3 weeks,4 weeks,5 weeks and 6 weeks after birth was lower than that of term babies(t=6.22?6.51?7.81?8.87? 10.25?11.64,all P<0.01);(4)There was no significant difference in the growth rate of corpus callosum between preterm infants and term children 0-62 weeks after birth(t=0.36,P>0.05).The growth rate of corpus callosum was significantly different between preterm infants in 2-6 weeks after birth(t = 13.91?14.76?13.85?12.21,all P <0.01).Conclusion(1)To identify the risk factors of intraventricular hemorrhage in newborns,strengthen prevention and treatment measures,and to prevent and treat periventricularintraventricular hemorrhage in neonates;(2)The development of the corpus callosum is related to gestational age and birth weigh;(3)Cranial ultrasound can dynamically monitored the growth and development of the corpus callosum. |
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